BAY-850|CAS 2099142-76-2|DC Chemials

Cas No.:	2099142-76-2
Chemical Name:	BAY-850
Synonyms:	BAY-850;N-[(2S)-1-[(4-Aminocyclohexyl)amino]-3-(4-cyanophenyl)propan-2-yl]-2-chloro-4-methoxy-5-[5-[[[(1S)-1-(4-methylphenyl)ethyl]amino]methyl]furan-2-yl]benzamide
SMILES:	ClC1=CC(=C(C2=CC=C(CN[C@@H](C)C3C=CC(C)=CC=3)O2)C=C1C(N[C@@H](CC1C=CC(C#N)=CC=1)CNC1CCC(CC1)N)=O)OC
Formula:	C₃₈H₄₄ClN₅O₃
M.Wt:	654.240668296814
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	BAY-850 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC50 of 166 nM.
In Vitro:	BAY-850 competes with the binding of a mono-acetylated Histone H4 N-terminal peptide to ATAD2 BD with an IC50 of 166 nM measured in TR-FRET assay. BAY-850 displaces the tetra-acetylated peptide with an IC50 of 157 nM and a KD of 115 nM respectively. The unprecedented isoform selectivity of BAY-850 suggests a different mode of action to those exhibited by canonical BD inhibitors[1].
References:	[1]. Fernández-Montalván AE, et al. Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action. ACS Chem Biol. 2017 Nov 17;12(11):2730-2736.

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