YKP-3089|cas 913088-80-9|DC Chemicals

Cas No.:	913088-80-9
Chemical Name:	Cenobamate
Synonyms:	Cenobamate;P85X70RZWS;YKP3089;Cenobamate [INN];Cenobamate (USAN/INN);Cenobamate [USAN:INN];Carbamic acid (R)-(+)-1-(2-chlorophenyl)-2-(2H-tetrazol-2-yl)ethyl ester;2H-Tetrazole-2-ethanol, alpha-(2-chlorophenyl)-, 2-carbamate, (alphaR)-;DB06119;2H-Tetrazole-2-ethanol, alpha-(2-chlorophenyl)-, carbamate (ester), (alphaR)-;D11150;Q27286352;2H-Tetrazole-2-ethanol, α-(2-chlorophenyl)-, carbamate (ester), (αR)- (9CI);(1R)-1-(2-chlorophenyl)-2-(2H-tetrazol-2-yl)ethyl carbamate;Xcopri;YKP 3089
SMILES:	[C@H](C1C=CC=CC=1Cl)(OC(=O)N)CN1N=NC=N1
Formula:	C₁₀H₁₀ClN₅O₂
M.Wt:	267.671700000763
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Cenobamate, a sodium channel blocker, enhances GABAergic transmission and has the potential to be a versatile CNS drug.

In Vivo:

Cenobamate (YKP3089) protects against MES induced seizures in mice with an ED50 of 9.8 mg/kg i.p., and in rats with an ED50 of 1.9 mg/kg p.o. In the sc Met seizures model, Cenobamate given ip inhibited the clonic seizures in mice and rats, with ED50 values of 28.5 and 13.6 mg/kg, respectively. Cenobamate is also effective against seizure induced by picrotoxin with an ED50 of 34.5 mg/kg in mice. Cenobamate is effective in reducing significantly the expression of stage 5 seizures in the hippocampal kindled rat (ED50=16.4 mg/kg). Cenobamate is effective in the mouse 6 Hz psychomotor seizure model at 22, 32 and 44 mA, with ED50 values of 11.0, 17.9 and 16.5 mg/kg, respectively. Cenobamate also protects against lithiumpilocarpine-induced intractable seizures in rats (ip) (ED50=7.0 mg/kg)[2].

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