Enzalutamide carboxylic acid (MDV3100 carboxylic acid) | Drug Metabolite

Cas No.:	1242137-15-0
Chemical Name:	Enzalutamide Carboxylic Acid
Synonyms:	Desmethyl-enzalutamide;Enzalutamide Carboxylic Acid;Enzalutamide carboxylic acid
SMILES:	CC1(C)C(=O)N(C2=CC(=C(C=C2)C#N)C(F)(F)F)C(=S)N1C3=CC(=C(C=C3)C(=O)O)F
Formula:	C₂₀H₁₃F₄N₃O₃S
M.Wt:	451.394
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Enzalutamide carboxylic acid (MDV3100 carboxylic acid) is an inactive metabolite of Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist[1].
In Vitro:	Enzalutamide is converted into its major metabolites, N-desmethyl enzalutamide and carboxylic acid enzalutamide, by cytochrome P450 (CYP) 3A4/5 and CYP2C8, respectively. N-desmethyl enzalutamide has clinically relevant anti-androgen capacities similar to enzalutamide, whereas carboxylic acid enzalutamide is inactive[1].
References:	[1]. van Nuland M, et al. Exposure-Response Assessment of Enzalutamide and Its Major Metabolites in a Real-World Cohort of Patients with Metastatic Castration-Resistant Prostate Cancer. Pharmacotherapy. 2019 Dec;39(12):1137-1145.

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