N-Desmethyl Pimavanserin (AC-279) | 5-HT2A Inverse Agonist

Cas No.:	639863-77-7
Chemical Name:	N-Desmethyl Pimavanserin
Synonyms:	CXL6LOR95E;N-Desmethyl-pimavanserin;n-(4-fluorobenzyl)-n-(piperidin-4-yl)-n'-(4-isobutyloxybenzyl)carbamide;Urea, N-((4-fluorophenyl)methyl)-N'-((4-(2-methylpropoxy)phenyl)methyl)-N-4-piperidinyl-;Unii-cxl6lor95E;AC-279;N-Desmethyl Pimavanserin
SMILES:	FC1C=CC(=CC=1)CN(C(NCC1C=CC(=CC=1)OCC(C)C)=O)C1CCNCC1
Formula:	C₂₄H₃₂FN₃O₂
M.Wt:	413.528189659119
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Vanover KE, et al. Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006 May;317(2):910-8.

Description:	N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.
In Vitro:	The mean plasma half-lives for Pimavanserin and its metabolite N-Desmethyl Pimavanserin (AC-279) are 57 hours and 200 hours, respectively.
References:	[1]. Vanover KE, et al. Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006 May;317(2):910-8.

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