Hydroxybupropion |cas 92264-81-8| DC Chemicals

Cas No.:	92264-81-8
Chemical Name:	Hydroxybupropione
Synonyms:	1-(3-Chlorophenyl)-2-[(1-hydroxy-2-methylpropan-2-yl)amino]propan-1-one
SMILES:	OCC(C)(C)NC(C)C(=O)C1=CC(Cl)=CC=C1
Formula:	C₁₃H₁₈NO₂Cl
M.Wt:	255.74052
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Hydroxybupropion is the major active metabolite of Bupropion. Hydroxybupropion is metabolized by CYP2B6.Bupropion is an atypical antidepressant and smoking-cessation agent. Hydroxybupropion inhibits norepinephrine uptake with an IC50 value of 1.7 μM. Hydroxybupropion is also a nACh receptor antagonis tis more potent than Bupropion[1] .
Target:	IC50: 1.7 μM (Norepinephrine uptake)[1] nACh receptor[1]
References:	[1]. Damaj MI, et al. Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors. Mol Pharmacol. 2004 Sep;66(3):675-82

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