Ritodrine hydrochloride (DU21220 hydrochloride)

Cas No.:	23239-51-2
Chemical Name:	ritodrine hydrochloride
Synonyms:	ritodrine hydrochloride;Ritodrine HCl;DU21220;Ritodrine;Ritodrine Hydrochlor;Miolene;N-(4-Hydroxyphenethyl)-4-hydroxynorephedrine Hydrochloride;N-(p-Hydroxyphenethyl)-4-hydroxynorephedrine hydrochloride;Prempar;Pre-Pa;pre-par;Ritodrine (hydrochloride);ritodrine(erythro);Utemerin;utopar;Yutopar;Ritodrine hydrochloride;(R,S)-4-Hydroxy-alpha-[1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]benzyl alcohol hydrochloride
SMILES:	Cl.O[C@@H]([C@H](C)NCCC1C=CC(=CC=1)O)C1C=CC(=CC=1)O
Formula:	C₁₇H₂₂ClNO₃
M.Wt:	323.814484119415
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Ritodrine hydrochloride (DU21220 hydrochloride) is a β-2 adrenergic receptor agonist.Target: β-2 Adrenergic ReceptorRitodrine is a tocolytic drug, used to stop premature labor. Ritodrine can significantly prolong a short interval more quickly but with relatively more side effects than magnesium sulphate. Stratified RCTs for different gestational ages and different labour stages should be designed for further study [1]. Ritodrine is a beta-2 adrenergic receptor agonist - a class of medication used for smooth muscle relaxation. Since ritodrine has a bulky N-substituent, it has high β2-selectivity. Also, the 4'-hydroxy on the benzene ring is important for activity as it is needed to form hydrogen bonds. However, the 4'-hydroxy makes it susceptible to metabolism by COMT. Since it is β2-selective it is used for premature labor [2].

References:

[1]. Li, X., Y. Zhang, and Z. Shi, Ritodrine in the treatment of preterm labour: a meta-analysis. Indian J Med Res, 2005. 121(2): p. 120-7. [2]. Medicinal Chemistry of Adrenergics and Cholinergics

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