LYS05|cas 1391426-22-4|DC Chemicals

Cas No.:	1391426-22-4
Chemical Name:	LYS01 free base
Synonyms:	N2-(7-Chloro-4-quinolinyl)-N1-[2-[(7-chloro-4-quinolinyl)amino]ethyl]-N1-methyl-1,2-ethanediamine;LYS05;N1-(7-chloroquinolin-4-yl)-N2-(2-((7-chloroquinolin-4-yl)amino)ethyl)-N2-methylethane-1,2-diamine;Lys 01
SMILES:	ClC1C=C2C(C(NCCN(CCNC3C4C(=CC(Cl)=CC=4)N=CC=3)C)=CC=N2)=CC=1
Formula:	C₂₃H₂₃Cl₂N₅
M.Wt:	440.372
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Lys05 is a new lysosomal autophagy inhibitor which potently accumulates within and deacidifies the lysosome of both cells and tumors, resulting in sustained inhibition of autophagy and tumor growth.

Cat. No.	Product name	Field of application
DC11363	NSC 185058	NSC 185058 is an inhibitor of ATG4B, a cysteine protease that activates LC3B during the initiation of autophagy.
DC9702	MRT68921	MRT68921 is the most potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively.
DC9496	HG-10-102-01	HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2(IC50=23.3 nM) and the G2019S mutant(IC50=3.2 nM)
DC10778	YKL-06-061	YKL-06-061 is a potent and selective SIK (salt-inducible kinase) inhibitor.
DC12501	WNK-IN-11	WNK-IN-11 is a potent, selectiive and orally active inhibitor of WNK1 kinase.
DC9883	WNK463	WNK463 is a pan-WNK-kinase inhibitor. It potently inhibits the in vitro kinase activity of all four WNK family members (WNK1, WNK2, WNK3, and WNK4).
DC10378	Urolithin A	Urolithin A is an intestinal metabolite of ellagic acid with antioxidant and antiproliferative effects; inhibits T24 and Caco-2 cell growth with IC50 values of 43.9 and 49 μM, respectively.
DC10456	STF-62247	STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM).
DC9696	SMER28	SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells when supplied at 47 µM.
DC8316	SBI-0206965	SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor.