SMER28 |SMER-28|cas 307538-42-7

Cas No.:	307538-42-7
Synonyms:	SMER-28,SMER 28
SMILES:	C=CCNC1=NC=NC2=C1C=C(C=C2)Br
Formula:	C₁₁H₁₀BrN₃
M.Wt:	264.1
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

SMER28 is an autophagy activator acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide.

References:

[1]. Renna M et al. Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J Biol Chem. 2010 Apr 9;285(15):11061-7. [2]. Shen D et al. Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies. Cell Biochem Biophys. 2011 Jul;60(3):173-85. [3]. Tian Y et al. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J. 2011 Jun;25(6):1934-42.

Cat. No.	Product name	Field of application
DC11363	NSC 185058	NSC 185058 is an inhibitor of ATG4B, a cysteine protease that activates LC3B during the initiation of autophagy.
DC9702	MRT68921	MRT68921 is the most potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively.
DC9496	HG-10-102-01	HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2(IC50=23.3 nM) and the G2019S mutant(IC50=3.2 nM)
DC10778	YKL-06-061	YKL-06-061 is a potent and selective SIK (salt-inducible kinase) inhibitor.
DC12501	WNK-IN-11	WNK-IN-11 is a potent, selectiive and orally active inhibitor of WNK1 kinase.
DC9883	WNK463	WNK463 is a pan-WNK-kinase inhibitor. It potently inhibits the in vitro kinase activity of all four WNK family members (WNK1, WNK2, WNK3, and WNK4).
DC10378	Urolithin A	Urolithin A is an intestinal metabolite of ellagic acid with antioxidant and antiproliferative effects; inhibits T24 and Caco-2 cell growth with IC50 values of 43.9 and 49 μM, respectively.
DC10456	STF-62247	STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM).
DC9696	SMER28	SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells when supplied at 47 µM.
DC8316	SBI-0206965	SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor.