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Home > Inhibitors & Agonists > Autophagy > Salt Inducible Kinase (SIK)

YKL-06-061

Cat. No.: DC10778 Featured

Chemical Structure

2172617-15-9

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Field of application

YKL-06-061 is a potent and selective SIK (salt-inducible kinase) inhibitor.

Chemicals Properties Biological activity Related products COA MSDS Datasheet

Cas No.:	2172617-15-9
Chemical Name:	1-Cyclobutyl-3-(2,6-dimethylphenyl)-7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one
Synonyms:	YKL-06-061; YKL06-061; YKL 06-061; YKL-06061; YKL06061; YKL 06061
SMILES:	O=C1N(C2CCC2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4OC)=NC=C3CN1C6=C(C)C=CC=C6C
Formula:	C₃₀H₃₇N₇O₂
M.Wt:	527.3
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively[1].

Cat. No.	Product name	Field of application
DC10778	YKL-06-061	YKL-06-061 is a potent and selective SIK (salt-inducible kinase) inhibitor.
DC10824	ARN-3236	ARN-3236 is potent, orally active and selective SIK2 inhibitor. ARN-3236 inhibited the growth of 10 ovarian cancer cell lines at an IC50 of 0.8 to 2.6 μmol/L.

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