NSC-12|NSC12|small-molecule FGF trap

Cas No.:	102586-30-1
Synonyms:	NSC-12,NSC 12,NSC12
SMILES:	C[C@@]12[C@](CC[C@]2([H])[C@@H](O)CC(C(F)(F)F)(O)C(F)(F)F)([H])[C@@]3([H])[C@]([C@@]4(C(C[C@@H](O)CC4)=CC3)C)([H])CC1
Formula:	C₂₄H₃₄F₆O₃
M.Wt:	484.51
Purity:	>98%
Sotrage:	4°C for 1 year, -20°C for more than 2 years

Cat. No.	Product name	Field of application
DC47658	FGFR-IN-1	FGFR-IN-1 is a potent FGFR inhibitor with an IC50 of <100 nM for FGFR1, FGFR2, and FGFR3, respectively (patent US20130338134A1, example 219).
DC46931	Gunagratinib	Gunagratinib (ICP-192) is a low toxicity and orally active pan-FGFR (fibroblast growth factor receptors) inhibitor that potently and selectively inhibits FGFR activities irreversibly by covalent binding. Gunagratinib can be used for the research of cancer.
DC46449	FGFR1 inhibitor-2	FGFR1 inhibitor-2 is a FGFR1 inhibitor (IC50 is 4.55 μM in MDA-MB-231 cells). FGFR1 inhibitor-2 can be used for the research of metastatic triple-negative breast cancer.
DC45315	SU4984	SU4984 is a protein tyrosine kinase inhibitor, with an IC50 of 10-20 μM for fibroblast growth factor receptor 1 (FGFR1). SU4984 is also inhibits platelet-derived growth factor receptor, and insulin receptor. SU4984 can be used for the research of cancer.
DC28557	FGFR4-IN-4	FGFR4-IN-4 (compound 693) is a FGFR4 inhibitor with anti-tumor activity, extracted from patent WO2018113584A1.
DC9945	NSC-12	NSC12 is a PTX3-derived anti-FGF small molecule, inhibits FGF-dependent tumor growth, angiogenesis, and metastases,acts as a small-molecule FGF trap in cancer therapy.
DC9933	FGFR4-IN-1	FGFR4-IN-1 is a potent inhibiotr of FGFR4 with IC50 of 0.7 nM.