FGFR1 inhibitor-2|CAS 2410612-08-5|DC Chemicals

Cas No.:	2410612-08-5
Chemical Name:	FGFR1 inhibitor-2
SMILES:	FC(C=C1)=CC=C1C(C2=CC=C(F)C=C2)CCCCNC(NC3=CC=C([N+]([O-])=O)C(C(F)(F)F)=C3)=O
Formula:	C₂₅H₂₂F₅N₃O₃
M.Wt:	507.45
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC47658	FGFR-IN-1	FGFR-IN-1 is a potent FGFR inhibitor with an IC50 of <100 nM for FGFR1, FGFR2, and FGFR3, respectively (patent US20130338134A1, example 219).
DC46931	Gunagratinib	Gunagratinib (ICP-192) is a low toxicity and orally active pan-FGFR (fibroblast growth factor receptors) inhibitor that potently and selectively inhibits FGFR activities irreversibly by covalent binding. Gunagratinib can be used for the research of cancer.
DC46449	FGFR1 inhibitor-2	FGFR1 inhibitor-2 is a FGFR1 inhibitor (IC50 is 4.55 μM in MDA-MB-231 cells). FGFR1 inhibitor-2 can be used for the research of metastatic triple-negative breast cancer.
DC45315	SU4984	SU4984 is a protein tyrosine kinase inhibitor, with an IC50 of 10-20 μM for fibroblast growth factor receptor 1 (FGFR1). SU4984 is also inhibits platelet-derived growth factor receptor, and insulin receptor. SU4984 can be used for the research of cancer.
DC28557	FGFR4-IN-4	FGFR4-IN-4 (compound 693) is a FGFR4 inhibitor with anti-tumor activity, extracted from patent WO2018113584A1.
DC9945	NSC-12	NSC12 is a PTX3-derived anti-FGF small molecule, inhibits FGF-dependent tumor growth, angiogenesis, and metastases,acts as a small-molecule FGF trap in cancer therapy.
DC9933	FGFR4-IN-1	FGFR4-IN-1 is a potent inhibiotr of FGFR4 with IC50 of 0.7 nM.