NS-2028|NS2028,NS 2028|Purchase|DC CHEM

Cas No.:	204326-43-2
Synonyms:	NS2028,NS 2028,NS-2028
SMILES:	O=C1ON=C2COC3=CC=C(Br)C=C3N21
Formula:	C₉H₅BrN₂O₃
M.Wt:	269.051
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). Blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC50 values are 17 and 20 nM respectively). Inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).. For the detailed information of NS-2028, the solubility of NS-2028 in water, the solubility of NS-2028 in DMSO, the solubility of NS-2028 in PBS buffer, the animal experiment (test) of NS-2028, the cell expriment (test) of NS-2028, the in vivo, in vitro and clinical trial test of NS-2028, the EC50, IC50,and affinity,of NS-2028, Please contact DC Chemicals.

Cat. No.	Product name	Field of application
DC47004	Mosliciguat	Mosliciguat is a guanylate cyclase activator.
DC46515	MM 419447	MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C).
DC44916	Guanylate cyclase-IN-1	Guanylate cyclase-IN-1 (Example 46) is a guanylate cyclase inhibitor that can be used for cardiovascular diseases research.
DC41630	Guanylin(human) TFA	Guanylin(human) TFA, a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) TFA is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism.
DC41629	Guanylin(human)	Guanylin(human), a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism.
DC7787	NS-2028	NS 2028 is a specific inhibitor of soluble guanylyl cyclase.
DC11995	BI 703704	A novel potent soluble guanylate cyclase (sGC) activator.