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| Cas No.: | 39562-70-4 |
| SMILES: | CCOC(C1C(C)=NC(C)=C(C(OC)=O)[C@H]1C1=CC=CC([N+]([O-])=O)=C1)=O |
| Formula: | C18H20N2O6 |
| M.Wt: | 360.36 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | Nitrendipine is a calcium channel blocker with marked vasodilator action.Nitrendipine is a dihydropyridine calcium channel blocker. It is used in the treatment of primary hypertension to decrease blood pressure. Nitrendipine blocked Ca2+ currents very potently, with half-block by subnanomolar concentrations. The concentration dependence of block had the form expected for 1:1 binding, with an apparent dissociation constant (Kd) of 0.36 nM. In contrast, when cells were held at hyperpolarized potentials, nitrendipine blocked Ca2+ currents much less potently (Kd approximately equal to 700 nM). Nitrendipine, a potent analogue of nifedipine, binds in a reversible and saturable manner to partially purified guinea-pig heart membranes. [3H]nitrendipine binding in smooth muscle is to a site which mediates the pharmacologic response. |