Vipadenant|CAS 442908-10-3|DC Chemicals

Cas No.:	442908-10-3
Chemical Name:	BIIB-014,BIIB 014,BIIB014
Synonyms:	BIIB-014,BIIB 014,BIIB014
SMILES:	CC1=C(C=CC(=C1)CN2C3=NC(=NC(=C3N=N2)C4=CC=CO4)N)N
Formula:	C₁₆H₁₅N₇O
M.Wt:	321.34
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Vipadenant is an adenosine receptor antagonist, with Kis of 1.3 nM and 68 nM for A2A and A1, respectively.

In Vivo:

Vipadenant (0.3-30 mg/kg) produces a dose-dependent reduction in catalepsy. Vipadenant (10 mg/kg) does not produce any statistically significant dyskinetic episodes in 6-OHDA-lesioned rats during a 19-day dosing regimen[1]. In the mouse and rat haloperidol-induced hypolocomotion models, vipadenant has a minimum effective dose of 0.1 and 1 mg/kg, respectively. Vipadenant (3 and 10 mg/kg, p.o.) is able to increase contralateral rotations in 6-OHDA lesioned rats[2].

Cat. No.	Product name	Field of application
DC28031	AB928	AB928 is an orally bioavailable, selective dual adenosine receptor (A2aR/A2bR) antagonist with immunomodulatory activity.
DC7780	ZM241385	ZM 241385 is a Potent A2 adenosine receptor antagonist, with approx 50-fold selectivity for A2A receptors.
DC8814	Vipadenant	Vipadenant(BIIB-014) is an adenosine A2a antagonist with Ki of 1.3 nM; less potent for A1(Ki=69 nM).
DC9805	Preladenant(SCH420814)	Preladenant(SCH 420814) is a potent and selective antagonist at the adenosine A2A receptor.
DC8471	CGS 21680 hydrochloride	CGS 21680 hydrochloride is an A2A adenosine receptor agonist (Ki = 27 nM).
DC10440	Namodenoson (CF-102)	CF-102(2-Cl-IB-MECA) is a selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively. target: A3 adenosine receptor agonist;
DC10739	AZD4635	AZD4635 is a novel adenosine 2A receptor (A2AR) inhibitor with a Ki of 1.7 nM.