BPR1R024|CAS 2503015-75-4|DC Chemicals

Cas No.:	2503015-75-4
Chemical Name:	Urea, N-[4-[[7-(dimethylamino)-4-quinazolinyl]oxy]phenyl]-N'-[[6-(trifluoromethyl)-3-pyridinyl]methyl]-
Synonyms:	BPR1R024
SMILES:	C1(=NC=C(CNC(=O)NC2=CC=C(C=C2)OC2=NC=NC3=CC(N(C)C)=CC=C23)C=C1)C(F)(F)F
Formula:	C₂₄H₂₁F₃N₆O₂
M.Wt:	482.46
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC47703	BPR1R024	BPR1R024 is an orally active and selective CSF1R inhibitor with IC50 of 0.53 nM. BPR1R024 specifically inhibits protumor M2-like macrophage survival with a minimal effect on antitumor M1-like macrophage growth.
DC8158	Pexidartinib(PLX3397)	PLX3397 is a tyrosine kinase inhibitor that potently inhibits the colony stimulating factor 1 (CSF1) receptor kinase, a driving force in the development and growth of PVNS.
DC7168	Ki20227	Ki-20227 is a highly selective c-Fms tyrosine kinase(CSF1R) inhibitor with IC50 value of 2 nM; 6 fold and > 100 fold selectivity over VEGFR2(IC50=12 nM) and c-Kit/PDGFR_beta_(IC50=451/217 nM), respectively.
DC1018	GW-2580 (GW2580)	GW2580 is a selective inhibitor of human c-FMS with IC50 of 30 nM.
DC11398	Edicotinib（JNJ-40346527）	Edicotinib（JNJ-40346527）is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity.
DC8103	BLZ-945	BLZ945 is a highly selective and brain-penetrant inhibitor of CSF1R with IC50 of 1 nM; >3200-fold higher than its affinity for other kinases.