DFV890|CAS 2271394-34-2|DC Chemicals

Cas No.:	2271394-34-2
Chemical Name:	NLRP3 antagonist 2
Synonyms:	NLRP3 antagonist 2;CS-0889900;EX-A8315;SCHEMBL23456785;(R)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-2-(2-hydroxypropan-2-yl)thiazole-5-sulfonimidamide;DFV 890;HY-155876;2271394-34-2
SMILES:	S(C1=CN=C(C(C)(C)O)S1)(=N)(NC(NC1=C2CCCC2=CC2CCCC=21)=O)=O
Formula:	C₁₉H₂₄N₄O₃S₂
M.Wt:	420.548861503601
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC73526	DFV890	DFV890 (IFM-2427) is apotent, selective and orally active inhibitor of NLRP3 inflammasome, directly binds to NLRP3 and locks the protein in an inactive conformation,prevents NLRP3 inflammasome assembly in response to sterile danger signals.
DC47029	Selnoflast	Selnoflast (example 6) is a NLRP3 inhibitor (extracted from patent WO2019008025).
DC45911	JC124	JC124 is a specific NLRP3 inflammasome inhibitor. JC124 has anti-inflammatory and neuroprotective effects.
DC44153	MCC7840	MCC7840, a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. MCC7840 can be used for the research of inflammatory diseases.
DC44152	Emlenoflast sodium (MCC7840 sodium)	MCC7840 sodium, a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. MCC7840 sodium can be used for the research of inflammatory diseases.
DC40974	GSK717	GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells.