GNE-064|CAS 1997321-20-6|DC Chemicals

Cas No.:	1997321-20-6
Chemical Name:	US10308614, Example 131
Synonyms:	GNE064;GTPL12206;BDBM394530;US10308614, Example 131;compound 5 [PMID: 35930799];(R)-1-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-2-methylpiperazin-1-yl)ethan-1-one;1-[(2R)-4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]-2-methylpiperazin-1-yl]ethanone;Ethanone, 1-[(2R)-4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-2-methyl-1-piperazinyl]-
SMILES:	O=C(C([H])([H])[H])N1C([H])([H])C([H])([H])N(C2C(N([H])[H])=NN=C(C3=C([H])C([H])=C([H])C([H])=C3O[H])C=2[H])C([H])([H])[C@@]1([H])C([H])([H])[H]
Formula:	C₁₇H₂₁N₅O₂
M.Wt:	327.3809
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC72030	GNE-064	GNE-064 (compound 5) is a selective, oral and highly soluble inhibitor of the SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 μM and inhibits SMARCA2 with an EC50 of 0.10 μM. GNE-064 possess Kds with 0.01, 0.016, 0.018 and 0.049 μM for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of drug synthesis.
DC48139	NVS-BET-1	NVS-BET-1 is a BET bromodomain inhibitor that regulates keratinocyte plasticity.
DC46835	Ziftomenib	Ziftomenib is a menin-MLL interaction inhibitor with antitumor activities (WO2017161028A1, compound 151).
DC46500	I-BET282E	I-BET282E is a pan-inhibitor of all eight BET bromodomains, and selectivity over other representative bromodomain-containing proteins. I-BET282E shows pIC50s ranging 6.4-7.7 for BRD2 (BD1/BD2), BRD2 (BD1/BD), BRD3 (BD1/BD), and BRD4 (BD1/BD).
DC46003	GSK097	GSK097 is a potent and selective Inhibitor of the second bromodomain (BD2) of the bromodomain and extra-terminal domain (BET) proteins. GSK097 displays 2000-fold selective for BD2 over BD1 (BRD4 data) with >1 mg/mL solubility in FaSSIF media.