GSK097|CAS 2159137-02-5|DC Chemicals

Cas No.:	2159137-02-5
Chemical Name:	GSK097
Synonyms:	2,4-Pyridinedicarboxamide, 6-[(S)-hydroxyphenylmethyl]-N2-methyl-N4-[(1S,2S)-2-methylcyclopropyl]-;GSK097
SMILES:	C1(C(NC)=O)=NC([C@@H](O)C2=CC=CC=C2)=CC(C(N[C@H]2C[C@@H]2C)=O)=C1
Formula:	C₁₉H₂₁N₃O₃
M.Wt:	339.39
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC72030	GNE-064	GNE-064 (compound 5) is a selective, oral and highly soluble inhibitor of the SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 μM and inhibits SMARCA2 with an EC50 of 0.10 μM. GNE-064 possess Kds with 0.01, 0.016, 0.018 and 0.049 μM for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of drug synthesis.
DC48139	NVS-BET-1	NVS-BET-1 is a BET bromodomain inhibitor that regulates keratinocyte plasticity.
DC46835	Ziftomenib	Ziftomenib is a menin-MLL interaction inhibitor with antitumor activities (WO2017161028A1, compound 151).
DC46500	I-BET282E	I-BET282E is a pan-inhibitor of all eight BET bromodomains, and selectivity over other representative bromodomain-containing proteins. I-BET282E shows pIC50s ranging 6.4-7.7 for BRD2 (BD1/BD2), BRD2 (BD1/BD), BRD3 (BD1/BD), and BRD4 (BD1/BD).
DC46003	GSK097	GSK097 is a potent and selective Inhibitor of the second bromodomain (BD2) of the bromodomain and extra-terminal domain (BET) proteins. GSK097 displays 2000-fold selective for BD2 over BD1 (BRD4 data) with >1 mg/mL solubility in FaSSIF media.