NSC74429|CAS 7255-94-9|DC Chemicals

Cas No.:	7255-94-9
Chemical Name:	Thiourea,N,N'-di-1H-indazol-6-yl-
Synonyms:	Thiourea,N,N'-di-1H-indazol-6-yl-;1,3-bis(1H-indazol-6-yl)thiourea;AC1MHFLR;AG-G-85832;CHEMBL1269022;CTK5D6475;N,N'-Di(1H-indazol-6-yl)thiourea;NCIStruc1_001450;NCIStruc2_001332;NSC74429;NSC-74429
SMILES:	N1C2C(=CC=C(NC(NC3C=C4C(C=NN4)=CC=3)=S)C=2)C=N1
Formula:	C₁₅H₁₂N₆S
M.Wt:	308.36098
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC73792	NSC74429	NSC74429 is a CNS-active, small molecule PHLPP inhibitor with IC50 of <5 uM, shows neuroprotective activity in primary rat cortical neurons in STS assay.
DC73789	K306	K306 is a small molecule agonist that specifically targets SH2-containing 5' inositol phosphatase 1 (SHIP1), an enzyme involved in regulating cellular signaling pathways. SHIP1 is a lipid phosphatase that hydrolyzes the 5' phosphate of phosphatidylinositol-3,4,5-trisphosphate (PIP3), converting it to phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2). This activity modulates the PI3K (phosphoinositide 3-kinase) signaling pathway, which is critical for cell survival, proliferation, and immune responses.
DC73788	K161	K161 is a potent, pan-SHIP1/2 inhibitor with IC50 of 1.5- 6 uM and 6.5-13 uM, respectively.
DC50265	GDC-1971	GDC-1971 showed outstanding potency in biochemical and cell models, and it had a predicted human PK profile that suggested it would achieve target engagement at reasonable doses. GDC-1971 showed an IC50 below the limit of detection of the assay (≪0.001 μM), while that IC50 shifted to 0.17 μM in the same biochemical assay with the constitutively active E76K SHP2 mutant.
DC47388	PROTAC SHP2 degrader-1	PROTAC SHP2 degrader-1 is a potent and effective SHP2 degrader. PROTAC SHP2 degrader-1 induces SHP2 degradation requires binding to VHL-1 and SHP2 proteins and is also neddylation- and proteasome-dependent.
DC47165	CDC25B-IN-2	CDC25B-IN-2 is a potent cdc25B inhibitor.
DC39105	SC-43	SC-43, a sorafenib derivative, is an agonist of Src-homology protein tyrosine phosphatase-1 (SHP-1/PTPN6) and reduces liver fibrosis. SC-43 reduces p-STAT3 and induces apoptosis with anti-tumor activity.
DC28481	(E/Z)-BCI(DUSP6 inhibitor)	(E/Z)-BCI (NSC 150117) is a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory activities. (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway.
DC11528	Razuprotafib	Razuprotafib is a potent protein tyrosine phosphatase β (HPTPβ) inhibitor..
DC11638	BCI(NSC 150117)	BCI is A small-molecule, allosteric inhibitor of DUSP6 (dual-specificity phosphatase 6) with IC50 of 12.3 uM; also inhibits human DUSP1 with IC50 of 11.5 uM; suppresses the ERK-induced activation of Dusp6 and regulates heart size in zebrafish.