trans-R-138727MP|CAS 929211-64-3|DC Chemicals

Cas No.:	929211-64-3
Chemical Name:	PRASUGREL METABOLITE R-138727MP
Synonyms:	PRASUGREL METABOLITE R-138727MP;(2Z)-2-[1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-[2-(3-methoxyphenyl)-2-oxoethyl]sulfanylpiperidin-3-ylidene]acetic acid;CIS R-138727MP, (PRASUGREL METABOLITE DERIVATIVE)(MIXTURE OF DIASTEREOMERS);cis R-138727MP, (Prasugrel Metabolite Derivative)(Mixture of Diastereomers)(Discontinued);Prasugrel Metabolite Derivative (trans R-138727MP, Mixture of Diastereomers)
SMILES:	COC1=CC(=CC=C1)C(=O)CSC2\C(=C/C(O)=O)CN(CC2)C(C(=O)C3CC3)C4C(F)=CC=CC=4
Formula:	C₂₇H₂₈NO₅FS
M.Wt:	497.57832
Purity:	>98%
Sotrage:	Please store the product under the recommended conditions in the Certificate of Analysis.

Cat. No.	Product name	Field of application
DC40984	trans-R-138727MP	trans-R-138727MP (Prasugrel metabolite R-138727MP) is the active metabolite derivative of Prasugrel. Prasugrel, a thienopyridine and prodrug, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.
DC1101	Ticagrelor (Brilinta,AZD6140)	Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist, also inhibits CYP2C9 and 4-hydroxylation with IC50 of 10.5 μM and 8.2 μM respectively.
DC7203	MRS 2578	MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors.
DC76635	NSC380324	NSC380324 is a P2Y12 receptor antagonist, possessing antiplatelet activity, and can be utilized in research on atherosclerotic cardiovascular diseases.
DC76634	MRS2905 trisodium	MRS2905 (α,β-Methylene-2-thio-UDP) trisodium is a selective P2Y14R agonist with an EC50 of 0.92 nM. MRS2905 trisodium is inactive at the UDP-activated P2Y6 receptor, and at other P2Y receptors.
DC76633	Becondogrel	Becondogrel (2-Oxoclopidogrel) is the metabolite of Clopidogrel, a dihydroorotate dehydrogenase (DHODH) inhibitor with antiviral activity.
DC73485	MRS4853	MRS4853 is a selective P2Y6 receptor (P2Y6R) antagonist with IC50 of 0.46 uM (hP2Y6R), displays weak affinity for mP2Y6R (IC50=6.15 uM).
DC73484	MRS4833	MRS4833 is a potent, selective antagonist of Gi protein-coupled P2Y14 receptor (P2Y14R, GPR105) with IC50 of 5.9 nM, Ki of 3.44 nM (human P2Y14R).
DC72346	MRS2279 diammonium	MRS2279 diammonium is a selective and high affinity P2Y1 receptor antagonist, with a Ki value of 2.5 nM and an IC50 value of 51.6 nM. MRS2279 diammonium competitively inhibits ADP-promoted platelet aggregation with an pKb value of 8.05.
DC72345	PIT	PIT (2,2'-Pyridylisatogen tosylate) is a selective and non-competitive antagonist of P2Y1 receptor with an IC50 value of 0.14 μM for human P2Y1 receptor. PIT antagonizes P2Y1 receptor signaling without affecting nucleotide binding. PIT is an irreversible antagonist of responses to ATP at metabotropic purinoceptors (of the P2Y family) in some smooth muscles. PIT can be used for the research of chronic bronchitis and asthma.