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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC49991 1,2-Dilauroyl-sn-glycerol Featured
1,2-Dilauroyl-sn-glycerol is a saturated diacylglycerol and may play a role in second messenger signal transduction.
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DC71606 (Rac)-IBT6A Featured
IBT6A (BTK inhibitor 1) is an impurity of Ibrutinib, which is a Btk inhibitor (IC50=0.5 nM), and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.
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DC42470 Sodium oleate Featured
Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium. Sodium oleate is a Na+/K+ ATPase activator.
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DC33202 Benzethonium Chloride Featured
Benzethonium Chloride, also known as Hyamine, is synthetic quaternary ammonium salt that has surfactant, antiseptic, and anti-infective properties. Benzethonium Chloride is commonly used as a topical antimicrobial agent. Benzethonium chloride exhibited concentration-dependent inhibitions of HERG channel currents with IC(50) values of 4nM and 17nM, respectively, which were also voltage-dependent and use-dependent. Benzethonium Chloride shifted the channel activation I-V curves in a hyperpolarized direction for 10-15mV and accelerated channel activation and inactivation processes by 2-fold.
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DC37279 Cetylpyridinium chloride Featured
Cetylpyridinium chloride is a Germicide, Bactericide, and Disinfectant.
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DC41235 Phenoxyethanol Featured
Phenoxyethanol has a broad spectrum of antimicrobial activity against various gram-negative and gram-positive bacteria. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al.
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DC41148 1,3-Butanediol Featured
1,3-Butanediol, an ethanol dimer providing a source of calories for human nutrition. 1,3-Butanediol is converted in the body to β-hydroxybutyrate and has cerebral protective and hypoglycaemic effect.
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DC31074 Isopropyl myristate Featured
Isopropyl myristate is the ester of isopropyl alcohol and myristic acid.
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DC12469 CYH33 Featured
CYH33 (CYH-33) is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively.
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DC31669 Dydrogesterone Featured
Dydrogesterone is a synthetic progestin. Dydrogesterone alone or in combination with estrogen to endothelial cells results in neutral effects on NO synthesis and on the activity and expression of eNOS. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation.
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DC12169 VU0463271
VU0463271 is a potent KCC2 antagonist, with an IC50 of 61 nM.
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DC71652 Alisporivir
Alisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity.
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DCC2242 GFB-12811 Featured
GFB-12811 is a high selective and orally active CDK5 inhibitor with an IC50 of 2.3 nM. GFB-12811 is highly selective over the other tested kinases (CDK1/2/6/7/9).
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DC24085 Rigosertib sodium Featured
Rigosertib sodium (ON 01910.Na) is a potent, non-ATP-competitive PLK1 inhibitor (IC50=9-10 nM), selectively induces mitotic G2/M arrest and apoptosis in cancer cells.
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DC36997 Acth (4-10) Featured
ACTH (4-10) is a water soluble potent melanocortin receptor agonist.
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DC31537 Amisulpride Featured
Amisulpride is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder. In Italy, it is also used as a treatment for dysthymia. It was introduced by Sanofi-Aventis in the 1990s. Its patent had expired by 2008 and hence generic formulations are now available.Amisulpride function primarily as a D2 and D3 receptor antagonist. It has high affinity for these receptors with dissociation constants of 2.2 nM and 2.4 nM, respectively. Although standard doses used to treat psychosis inhibit dopaminergic neurotransmission, low doses preferentially block inhibitory pre-synaptic autoreceptors.
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DC20123 EC0489
EC0489, a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor. Small molecule-drug conjugate (SMDC).
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DC20105 NMDAR antagonist 1 Featured
NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective NMDAR antagonist.
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DC12331 XRK3F2
XRK3F2 is an inhibitor of p62 (Sequestosome-1)-ZZ/ domain.
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DC20011 Tigecycline tetramesylate
Tigecycline tetramesylate (GAR-936 tetramesylate) is a broad-spectrum glycylcycline antibiotic. The mean inhibitory concentration (MIC) of Tigecycline for E. coli (MG1655 strain) is approximately 125 ng/mL. MIC50 and MIC90 are 1 and 2 mg/L for Acinetobact
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DC12204 Stearic acid
Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
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DC10405 SPACE peptide
SPACE peptide is a skin penetrating peptide which facilitates the delivery of molecules through the skin.
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DC20070 SGC3027
SGC3027 is a histone methyltransferase inhibitor. SGC3027 is the first potent, selective and cell active chemical probe for PRMT7.
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DC12301 Pepstatin Ammonium (Pepstatin A Ammonium)
Pepstatin Ammonium is a specific aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and he
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DC12200 PACAP (6-38), human, ovine, rat TFA
PACAP (6-38), human, ovine, rat is a potent PACAP receptor antagonist with IC50s of 30, 600, and 40 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2, respectively.
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DC8716 NU6300
NU6300 is a non-covalent ATP-competitive CDK2 inhibitor (IC50 = 0.16 mM).
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DC10302 N-deacetylated BMS-202
N-deacetylated BMS-202 is the deacetylated of BMS-202. BMS-202 is an inhibitor of the PD-l/PD-Ll interaction, mainly used for cancer treatment.
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DC12172 L-JNKI-1
L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK.
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DC12095 GRGDSP TFA
GRGDSP (TFA) is an integrin inhibitor.
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DC12343 GNE 220 Hydrochloride
GNE 220 (Hydrochloride) is a potent and selective inhibitor of MAP4K4, with an IC50 of 7 nM.
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