AG-538 is a PI5P4Kα inhibitor which targets the ATP site.

Bisindolylmaleimide VII is a selective inhibitor of protein kinase C.

Ascorbate, also known as Ascorbicin, is a DNase I inhibitor. Ascorbate is an antioxidant which functions as a reducing agent and coenzyme in several metabolic pathways.

Mafenide Hydrochloride is an antibiotic against many gram-positive and gram-negative organisms, including Pseudomonas aeruginosa.

Metominostrobin is a broad-spectrum fungicide.

GA3-AM is a cell permeable chemical dimerizer.

Fendiline HCl is a potent acid sphingomyelinase (ASM) inhibitor, reducing the phosphatidylserine (PtdSer) and cholesterol content of the inner plasma membrane and inhibiting calcium function in muscle cells in excitation-contraction coupling.

UK-78282 HCl is a blocker of the KV1.3 and KV1.4 voltage-gated potassium channels.

R(+)-6-Bromo-APB HBr is a potent D1 Dopamine receptor agonist.

RTC13 is a premature termination codon (PTC) readthrough inducer that acts by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy.

OG-L002 HCl is an inhibitor of LSD1.

PK-THPP is a TASK-3 channel blocker.

GSK837149A is the first selective inhibitor of human fatty acid synthase (FAS).

Seretide is a combination of fluticasone and salmeterol that is used as an inhaler formulation to manage the symptoms of asthma and chronic obstructive pulmonary disease (COPD).

U83836E is a potent lipid peroxidation (LP) inhibitor. It has been shown to suppress oxidative stress and activate PKC, improving neurodegeneration in diabetic retinopathy (DR).

Eprosartan is a competitive and reversible angiotensin II receptor antagonist used for the treatment of high blood pressure. The drug acts on the renin-angiotensin system to decrease total peripheral resistance in two ways. First, it blocks the binding of angiotensin II to AT1 receptors in vascular smooth muscle, causing vascular dilatation. Second, it inhibits sympathetic norepinephrine production, further reducing blood pressure.

Turimycin is a macrolide antibiotic that is effective against a wide spectrum of pathogens.

PF-06651481-00, also known as Bosutinib Isomer I, is an analog of bosutinib, and a Bcr-Abl kinase inhibitor.

MpsBAY2a is a potent and selective Mps1 inhibitor. It is selective for Mps1 over a panel of 220 kinases. MpsBAY2a differentially inhibits human colon carcinoma cell proliferation.

Rifampicin is a semisynthetic antibiotic produced from Streptomyces mediterranei with broad antibacterial spectrum. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme.

Fe-TMPyP is a peroxynitrite decomposition catalyst. Fe-TMPyP also binds to the prion protein PrP and inhibits misfolding.

R,R-THC is a estrogen receptor-β selective antagonist. R,R-THC also inhibits DHEA and DHEA metabolite transcriptional activity in ERβ-transfected cells. R,R-THC has also been shown to have neuroprotective effects against glutamate-induced death in primary rat cortical cells and mouse N29/4 hypothalamic cells.

(S)-Crizotinib is an MTH1 inhibitor. By inhibiting MTH1, (S)-Crizotinib disrupts nucleotide pool homeostasis, induces an increase in DNA single-strand breaks, activates DNA repair in human colon carcinoma cells, and effectively suppresses tumor growth in animal models.

Phosphoramidite for the synthesis of alkyne-modified oligonucleotides. Oligonucleotides can be used for Click Chemistry modification (see the protocol). Diluent for this amidite is acetonitrile, 5 min coupling time is recommended. Standard deprotection conditions can be used for oligonucleotides.

BDP FL azide is an analog of BODIPY FL azide, a Click-chemistry capable bright and photostable dye for FAM channel. This green-emitting fluorophore is compatible with all types of fluorescence measuring instruments for FAM (fluorescein) and dyes like Alexa Fluor 488. The fluorophore is a representative of borondipyrromethene class of fluorescent dyes, which possess high quantum yields in aqueous environments, and high stability towards photobleaching

Cyanine3 NHS ester is a reactive dye for the labeling of amino-groups in biomolecules, an analog of Cy3? NHS ester. This reagent is ideal for the labeling of soluble proteins, peptides, and oligonucleotides/DNA. For delicate proteins consider using water-soluble sulfo-Cyanine3 NHS ester which does not require use of any co-solvent. Cyanine3 NHS ester is a replacement for NHS esters of Cy3?, Alexa Fluor 546, and DyLight 549.

Potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β). Displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Decreases phosphorylation of microtubule-associated protein Tau in vitro; protects rat primary cortical neurons against β amyloid and glutamate challenge. Brain penetrant.

Nitrilotriacetic acid is a chelating agent. It is also used as a complexing agent, metal masking agent.

2-Acetyl-5-methylthiophene is a constituent of coffee aroma.

GZ-793A inhibits dopamine uptake at the vesicular monoamine transporter-2 (VMAT2. A lobelane analog, GZ-793A interacts with the vesicular monoamine transporter-2 to inhibit the effect of methamphetamine.