Selective orthosteric agonist of human FFA2

Natural potent colchicine site binding microtubule-destabilizing agent with anti-proliferation and anti-metastasis activity via PAK1 and p21-mediated signaling in breast cancer cells

Iron chelator, mediating iron transport in Streptomyces pilosus

Novel ferroptosis inducer, killing selected cancer cell lines by harnessing reactive oxygen species (ROS)

Novel oral iron therapy agent, being effective in correcting iron deficiency anemia in patients with inflammatory bowel disease

Non-steroidal antiinflammatory agent

Non-steroidal anti-inflammatory drug, being used for symptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain

Potent, selective, noncompetitive glutamate mGluR5 receptor antagonist

Novel potent antimalarial agent, binding to ferriprotoporphyrin-IX (FeIII-PPIX) (Kd = 33 nM) against chloroquine-resistant and sensitive strains of Plasmodium falciparum

Novel rapamycin derivative, targeting polycystic kidneys due to the high expression of the folate receptor (FRα), lacking the extra-renal effects of unconjugated rapamycin, in particular immunosuppressive effects

Novel phosphodiesterase 4 (PDE4) inhibitor with little emetic potential, blocking MPP+ induced oxidative damage in SH-SY5Y cells and neurons via AMPK-dependent autophagy

Specific inhibitor of inflammasome assembly, targeting the NLRP3 inflammasome by interfering with the proximity-induced autocleavage of procaspase-1

Novel CAIX inhibitor, inhibiting breast cancer invasion and metastasis

Novel potent αvβ3 antagonist. reducing GBM tumor growth and viability by up to 98%

First-in-class covalent allosteric inhibitor of fructose-1,6-bisphosphate aldolase (FBA) from Candida albicans (CaFBA)

Potent and selective dopamine D3 receptor partial agonist

Highly potent and selective dopamine D4 receptor agonist

Dopamine D4 receptor antagonist

Novel irreversible dopamine D2 receptor ligand, covalently binding the L94C mutant of the dopamine D2 receptor

Dopamine D4 receptor antagonist

Novel folate-targeted TLR7 agonist, selectively accumulating in profibrotic macrophages and suppressing fibrosis-inducing cytokine production, reprograming M2-like fibrosis-inducing macrophages into fibrosis-suppressing macrophages, resulting in dramatic

Novel fatty acid synthase (FASN)

Novel potent and specific fatty acid synthase (FASN) inhibitor

Novel inhibitor of C. difficile's FASII pathway

Novel folate-caged pomalidomide-based anaplastic lymphoma kinase (ALK) PROTAC, effectively degrading ALK fusion proteins in cancer cells in a FOLR1-dependent manner

Stable and persistent PKC activator

Inducer of apoptosis via regulation of L11 and c-Myc with combinational potential with anticancer drugs in non-small-cell lung cancers

Novel FAP-targeted NIR dye conjugate

Novel FAP-targeted Fluorescein dye conjugate

Inhibitor of neutrophil superoxide production