Potent and selective SIRT1 inhibitor

Novel glucagon-like peptide 1 (GLP-1) receptor agonist, displaying significantly elongated half-lives and improved long-acting antidiabetic activity in the presence of endogenous anti-DNP antibodies

Novel ALK5 inhibitor

Novel partial positive allosteric GABAA receptor modulator

Novel GluN2B antagonist, binding at the same GluN1/GluN2B dimer interface as ifenprodil but adopting a remarkably different binding mode involving a distinct subcavity and receptor interactions

Novel potent gamma-secretase modulator

The first plant cyclic peptide with antibacterial and antifungal activity

Scavenger for oxidative species such as peroxynitrite, superoxide, and hydrogen peroxide

Novel negative allosteric modulator (NAM) of NMDA receptors, reducing both the overall current that flows following receptor activation and the flux of Ca2+ ion relative to monovalent cations

Novel Biased modulator of NMDA receptors, controlling channel opening and ion selectivity

Novel broad-spectrum β-lactamase inhibitor

Potent and selective inhibitor of Pim 1, inhibiting the phosphorylation of Bad and 4EBP1 in cells and suppresses the proliferation of several non-solid and solid human tumor cell lines.

Pesticide, acting as antibiotics or growth regulators to kill mites and ticks

Partial agonist at the glutamate binding site of the GluN2 subunits

Novel enhancer of the religation reaction of human topoisomerase I

Activator of β2 and β3 subunit containing channels of the GABAA receptor complex, stimulating the production of GABA(A) active neurosteroids

TRPA1 channel agonist

Novel selective FTO inhibitor

Natural potent antiviral agent, significantly inhibiting coxsackievirus group B (CVB) replication both in vivo and in vitro

Novel anticancer agent

Cell-impermeant viability indicator, as high-affinity nucleic acid stain that is weakly fluorescent until bound to DNA and emits red fluorescence (excitation/emission maxima ~528/617).

Novel inhibitor of PORCN, inhibiting ß-catenin reporter activity in a dose-dependent manner

H-89 analog as PKA and AKT1 inhibitor with specificity on no longer inhibiting CAMK2B and neither affecting viability of mice nor causing any detectable tissuedamage at the dose given

Selective estrogen receptor modulator (SERM), exhibiting estrogen agonism in certain tissues and estrogen antagonism in others

Novel Highly Soluble σ1 Receptor Antagonist for Pain Management

Serotonin 5-HT2A Agonist

Broad-spectrum, topical macrolide antibiotic, diffusing through the bacterial cell membrane and reversibly binding to the 50S subunit of the bacterial ribosome

Precursor of adrenaline, suppressing the locomotor stimulation by MAO inhibitor

Anti-HBV agent, showing activities on HepG 2.2.15 cell line in vitro

Novel potent inhibitor of recombinant human and mouse Transglutaminase enzyme activity, mainly TG2 and the close related enzyme TG1