Novel inhibitor of ClpXP complexes, causing extremely rapid dissociation of ClpXP complexes, preventing ClpX rebinding following spontaneous dissociation

Novel Hsp40-Hsp70 chaperone complex inhibitor, inhibiting the Hsp40-stimulated ATPase activity of the Hsp70 chaperone, with a K i of ~10 μM

Potential antidepressant and anti-Parkinson agent

Potential antidepressant and anti-Parkinson agent

Novel potent inhibitor of the MDM2-p53 interaction

Novel selective USP8 inhibitor (USP8 IC50 2.1 μM; USP7 >50μM)

Novel selective HDAC6 inhibitor, showing 260-fold selectivity towards HDAC6 vs other HDACs

Novel potent activator of pan-AMPK, enhancing AMPK phosphorylation by upstream kinase LKB1 and protecting AMPK complex against dephosphorylation by PP2C

Novel Inhibitor of BRD4-Driven Nucleoporin NUP210 Expression, Attenuating Colorectal Cancer Growth

Novel potent and selective LpxC inhibitor

Antipsychotic, targeting the dopamine D2 receptor

Novel Inhibitor of Cellulose Synthesis

Analgesic, antipyretic, and anti-inflammatory agent

Selective Caspase-3 inhibitor

Highly photodurable and blue-laser excitable fluorescent amino acid. acting as a highly fluorescent probe after being incorporated into specific positions of various antibodies, receptors, and enzymes

Novel Acetyl-CoA Carboxylase 2 (ACC2) Selective Inhibitor, Improving Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways

Novel highly potent and selective acetyl-CoA carboxylase 1 (ACC1) inhibitor (hACC1: IC 50 =0.58nM, hACC2: IC 50 >10000nM)

Novel Selective, irreversible, and Rapid Cell-Permeable Inhibitor of Human Caspase-3

Novel, cell-permeable, potent O-GlcNAc transferase (OGT) inhibitor

Novel metabolic oligosaccharide engineering (MOE) reagent, being an efficient chemical tool to probe protein glycosylation

Novel metabolic oligosaccharide engineering (MOE) reagent, being an efficient chemical tool to probe protein glycosylation

Novel potent and specific inhibitor of janus kinase 2 (JAK2)

Novel potent and selective multidrug resistance-associated protein 1 (MRP1, ABCC1) modulator

Novel benzodiazepine receptor partial inverse agonist

Novel potent, nontoxic, and highly selective breast cancer resistance protein (BCRP) inhibitor

Prodrug of 4FGalNAz to label a variety of proteins in mammalian cells without perturbing endogenous glycosylation pathways and primarily act as a substrate for O-GlcNAc transferase (OGT)

Novel potent, nontoxic, and highly selective breast cancer resistance protein (BCRP) inhibitor

Novel inhibitor of Mycobacterium tuberculosis (Mtb), selectively killing Mtb at acidic pH and potentiating the bactericidal activity of isoniazid, clofazimine, and diamide

Novel inhibitor of Mycobacterium tuberculosis (Mtb) growth at acidic pH, killing Mtb by selectively depleting free thiols at acidic pH

Orally bioavailable M(1) muscarinic receptor allosteric agonist improving cognitive performance in an animal model