URB754 is reported to be a potent, noncompetitive inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme.

UPF1854 is a potent tankyrase inhibitor with IC50 of 12 nM and 200 nM for TNKS1 and TNKS-2 respectively, displays no cross-reactivity versus other PARP proteins.

UPC-K-005 is a novel p38 inhibitor, exhibiting a IC50 of 13 μM.

UniPR1331 (UniPR-1331) is a selective, orally available antagonist of Eph/ephrin interaction with pIC50 of 5.45, IC50 of 2.9 uM.

UNC4203 (UNC-4203) is a potent, highly selective MerTK with IC50 of 2.4 nM, displays >30- and 4 -foldfold selectivity over Alx (IC50=80 nM) and Tyro3 (IC50=9.1 nM).

UNC-2170 is a small molecule ligand for the methyl-lysine binding protein 53BP1 (p53-binding protein 1) with Kd of 22 uM against the 53BP1 tandem tudor domain.

UNC1666 is a potent, specific dual Mer and Flt3 tyrosine kinase inhibitor with IC50 of 0.55 and 0.69 nM.

UNC119-Src interaction inhibitor 3 is a potent, specific small molecule inhibitor of UNC119-Src interaction with IC50 of 12 nM for displacement of the Src peptide from UNC119A.

UNC-1062 is a potent and selective Mer kinase inhibitor with IC50 of 1.1 nM, Ki of 0.33 nM.

UNC0379 is a selective, +N2106:AC2106substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM, displays good selectivity over 15 other methyltransferases, including G9a and GLP (IC50>100 uM).

ULK1-IN-1 highly potent ULK1 inhibitor with IC50 of 8 nM, with no enough selectivity but sufficient potency, a cellular probe of autophagy..

ULK-100 (ULK100) is a potent and selective ULK1 inhibitor with in vitro IC50 of 1.6 nM, inhibits ULK2 with IC50 of 2.6 nM.

Ulinastatin (UTI) is a urinary trypsin inhibitor extracted and purified from urine of males.

UK-396082 is a potent and selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (activated TAFI.

UK-383367 (UK 383367) is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase) with IC50 of 44 nM; Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).

UK-371804 is a potent and selective uPA inhibitor with excellent enzyme potency (Ki 10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).

UK-369003 (Gisadenafil besylate) is a novel, potent, selective, orally bioavailable PDE5 inhibitor with IC50 of 1.23 nM, displays 117-fold selectivity over PDE6.

UK 356618 is a potent and selective MMP3 inhibitor with IC50 of 5.9 nM, shows >140-fold less potent against MMP-1 (IC50=51000 nM), MMP-2 (IC50=1790 nM), MMP-9 (IC50=840 nM) and MMP-14 (IC50=1900 nM).

UK 14,304 is a full α2-adrenergic receptor (α2-AR) agonist.

Udenafil is a new phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED)

UCT943 (UCT-943) is a potent, selective, next generation Plasmodium falciparum PI4K inhibitor with IC50 of 23 nM.

UCS15A is a small moelcule SH3 domain-mediated protein-protein interaction blocking agent that inhibits proline-rich ligand-mediated protein-protein interactions (PLPI).

UCPH-102 is a selective, brain penetrant inhibitor of EAAT1 (Excitatory amino acid transporter 1) with IC50 of 420 nM.

UCN-01 (7-Hydroxystaurosporine.

UC-112 is a novel IAP inhibitor that potently inhibits human melanoma (A375 and M14) and human prostate (PC-3 and DU145) cancer cell lines with IC50 of 0.7-3.4 uM.

Ubrogepant (MK-1602) is a novel potent, selective, oral calcitonin gene-related peptide receptor (CGRP) antagonist for acute treatment of migraine..

UBP 296 (UBP296, UBP-296) is a potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 1.09 uM.

Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.

UBE2M-DCN1 inhibitor 52 is a highly potent inhibitor of DCN1-UBE2M protein-protein interaction with IC50 of 60 nM, inhibits cullin neddylation in pulse-chase NEDD8 transfer assay with EC50 of 80 nM.

UAMC00039 dihydrochloride is a potent inhibitor of dipeptidyl peptidase II (DPP-II) (IC50 = 0.48 nM).