DYR530 is a high affinity DYRK1A inhibitor with Kd of 0.91 nM.

Milademetan (DS-3032) is a specific and orally active MDM2 inhibitor for the research of acute myeloid leukemia (AML) or solid tumors. Milademetan (DS-3032) induces G1 cell cycle arrest, senescence and apoptosis.

Osilodrostat (LCI699) phosphate is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC50 value of 35 nM. Osilodrostat phosphate is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC50 values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. Osilodrostat phosphate inhibits aldosterone and corticosterone synthesis. Osilodrostat phosphate has blood pressure lowering ability. Osilodrostat phosphate can be used for research of Cushing syndrome (CS).

The diselenide bond is an important chemical bond formed by two selenium atoms sharing a pair of electrons. Because the electronegativity of selenium atom is low, the bond energy of diselenide bond is low, so it has the characteristics of strong reactivity and easy to break. In polymer materials, the dynamic chemical properties of diselenide bond make it have a wide application prospect. The dynamic chemical properties of diselenide bond are mainly manifested in its easy fracture and formation. In polymer materials, diselenide bond fracture can be achieved by external stimuli (such as light, heat, electricity, etc.) or chemical reactions. For example, through the action of photosensitizer initiator, polymer materials containing diselenide bonds can be broken under ultraviolet irradiation, so as to achieve controlled degradation of materials. In addition to breaking, diselenide bonds can also form new bonds. In polymer materials, diselenide bonds can form new bonds by free radical reaction or nucleophilic substitution reaction. For example, through free radical reactions, polymer materials containing diselenide bonds can be reacted with other free radical reactants to form new bonds and achieve cross-linking or modification of materials. In addition, diselenide bonds can also form new bonds through nucleophilic substitution reactions, such as in the presence of nucleophilic reagents, diselenide bonds can be replaced, so as to achieve the functionalization or modification of materials.

IDE-397 (GSK-4362676, GSK-676) is a potent, selective small molecule methionine adenosyltransferase 2a (MAT2A) inhibitor, displays broad anti-tumor activity across a panel of MTAP-deleted patient-derived xenografts.

ERD-1233 is a potent and orally efficacious estrogen receptor α (ERα) degrader with DC50 of 0.9 nM. ERD-1233 does not display any liability in CYP inhibition, hERG inhibition, and microsomal and plasma stability. ERD-1233 effectively reduces ER protein in ER+ tumors and achieves tumor regression in the ER wild-type MCF-7 xenograft tumor model. ERD-1233 is a potent and orally efficacious estrogen receptor α (ERα) degrader with DC50 of 0.9 nM. ERD-1233 does not display any liability in CYP inhibition, hERG inhibition, and microsomal and plasma stability. ERD-1233 effectively reduces ER protein in ER+ tumors and achieves tumor regression in the ER wild-type MCF-7 xenograft tumor model.

Dicetylamine is a biochemical

1-Stearoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine sodium is a glycerophospholipid.

2-Oleoyl-1-stearoyl-sn-glycero-3-phosphocholine (1-Stearoyl-2-oleoyl-sn-glycero-3-PC) is an active compound. 2-Oleoyl-1-stearoyl-sn-glycero-3-phosphocholine can be used for various biochemical studies.

1,2-Dimyristoyl-sn-glycerol is a saturated diacylglycerol and a weak second messenger for the activation of PKC.

Trilinolein is an endogenous metabolite.

L-Dilinoleoyllecithin is a phosphatidylcholine (PC or GPCho). It is a glycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, glycerophosphocholines can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. Fatty acids containing 16, 18 and 20 carbons are the most common. PC(18:2(9Z,12Z)/18:2(9Z,12Z)), in particular, consists of two chains of linoleic acid at the C-1 and C-2 positions. The linoleic acid moieties are derived from seed oils. Phospholipids, are ubiquitous in nature and are key components of the lipid bilayer of cells, as well as being involved in metabolism and signaling.While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. PCs can be synthesized via three different routes. In one route, choline is activated first by phosphorylation and then by coupling to CDP prior to attachment to phosphatidic acid. PCs can also synthesized by the addition of choline to CDP-activated 1,2-diacylglycerol. A third route to PC synthesis involves the conversion of either PS or PE to PC.

rac-1,2-Distearoyl-3-chloropropanediol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

1-Stearoyl-2-myristoyl-sn-glycero-3-PC (1S-2M-PC) belongs to the class of asymmetric phospholipids. 1-Stearoyl-2-myristoyl-sn-glycero-3-PC is abundant in biological membranes.