Selective COX-2 inhibitor

Second-generation leukotriene B4 receptor antagonist

Matrix metalloproteinase (MMP) inhibitor, also acting as a collagenase inhibitor

Potent inhibitor of checkpoint kinase 2 (Chk2)

Novel obatoclax derivative, inducing apoptosis in hepatocellular carcinoma cells through SHP-1-dependent STAT3 inactivation

Novel Smac mimetic, demonstrating potent cell-killing effects in several subtypes of breast, ovarian, and prostate cancer cell lines but only when the DR ligand TRAIL or another such apoptosis inducer is co-administered

Inhibitor of S100B which selectively kills melanoma; Amoebicidal diamidine

Novel inhibitor of Quiescin Sulfhydryl Oxidase 1 (QSOX1), suppresses tumor cell growth in a Matrigel-based spheroid assay and inhibits invasion in a modified Boyden chamber, but does not affect viability of non-malignant cells

Novel potentiator of metabotropic glutamate receptors for use against neurological and psychiatric disorders

Novel potentiator of metabotropic glutamate receptors for use against neurological and psychiatric disorders

Membrane-permeant, fluorescent, selective Na+ indicator dye

Novel cAMP-independent potentiator of CFTR, synergistically restoring CFTR function

Novel cAMP-independent potentiator of CFTR, synergistically restoring CFTR function

Potent non-cytotoxic inhinitor of Mycobacterium tuberculosis H37Rv

Novel Rho kinase inhibitor

Novel inhibitor of mitogen and Stress-Activated Kinases 1 (MSK1)

Novel CXCR2 selective antagonist, inhibiting ex vivo neutrophil activation and ozone-induced airway inflammation in humans

Novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor

Potent and selective dopamine D3 receptor antagonist

Novel TRPV4 blocker

AntiMycobacterium tuberculosis agent

Selective p38a kinase inhibitor, inhibiting Brd4

Selective dopamine D3 receptor antagonist

Nonpeptidic antagonist of alpha(v)beta3 and alpha(v)beta5 integrins, reducing angiogenesis and VEGF expression

Novel selective mTOR inhibitor

Selective 5-HT7 receptor antagonist

Selective 5-HT2C_receptor>5-HT2C inverse agonist

Inhibitor of p38 MAPK

Potent and selective agonist for the human ß3-adrenoceptor

Potent, specific inhibitor of human p38 mitogen-activated protein (MAP) kinase