Novel photoswitchable sphingolipid probe, reversibly controlled S1P3-dependent pain hypersensitivity in mice and uniquely suited for the study of S1P biology in cultured cells and in vivo

Functionalized photoswitchable cereblon ligand for Degraders

Novel photocontrol inhibitor of the voltage-gated proton channel Hv1

Novel potent photoswitchable antagonist for a precise spatiotemporal control of β2-adrenoceptors

Novel photoswitchable BET bromodomain Degrader (PHOTAC)

Inducer of platelet aggregation, playing a role in cellular signal transduction and possibly in cell growth control and carcinogenesis

Sulindac derivative with promising anticancer activities

Potent antagonist of (H1N1)pdm09 infection, markedly suppressing cytopathic effects and attenuating viral gene expression in (H1N1)pdm09-infected MDCK cells

Natural anti-tumor agent, showing strong apoptotic anticancer effects against platinum-resistant solid cancers

Novel GPR173 agonist, promoting osteoblastic differentiation of MC3T3-E1 cells. stimulating mRNAs encoding hypothalamo-pituitary-gonadal hormones

Novel neuropeptide, protecting human brain vascular endothelial cells against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced inflammation and permeability, significantly ameliorating HFD-induced obesity and fatty liver, regulating pituitary gona

Novel selective α-syn ligand, exhibited the promising binding characteristics for α-syn aggregates (Ki = 0.52 nM)

Blocker of dsRNA-induced IRF3 nuclear translocation and homodimerization; Inhibitor of lipopolysaccharide-mediated Toll-like receptor-4 signaling; Inhibitor of human pancreatic cancer

Inhibitor of internalization of cell surface receptors and tyrosine phosphatases, with no effect on tyrosine kinase

Prodrug of phenoxodiol

Selective ligand of a specific G-quadruplex conformation, interacting with the quadruplex through extensive

Inhibitor of NMDA receptors, used as a veterinary anesthetic, and briefly as a general anesthetic for humans

Novel COX-2 inhibitor

Natural nicotinic acetylcholine receptor agonist

Inhibitor of phagocytosis, interacting with and inhibiting the activating Fc receptors on macrophages, inhibiting downstream signaling pathways driving Fc-mediated phagocytosis

Selective ATP competitive ALK inhibitor

Inhibitor of both Bcr-Abl tyrosine kinase and Aurora kinases

Glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) inhibitor

Novel potent matrix metalloproteinase (MMP) inhibitor, targeting MMPs 1, 3, 9, and 13 (24, 18, 1.9, and 1.3 nM, respectively)

Novel allosteric PGAM1 inhibitor, showing efficacious in multiple preclinical models of pancreatic ductal adenocarcinoma (PDAC), especially with high PGAM1 expression

Novel allosteric PGAM1 inhibitor, showing efficacious in multiple preclinical models of pancreatic ductal adenocarcinoma (PDAC), especially with high PGAM1 expression

Potent and selective antagonist of the VIP1 receptor, inhibiting competitively effect of VIP on the VIP1 receptor mediated stimulation of adenylate cyclase activity with Ki values respectively of 15 ± 5 nM and 2 ± 1 nM for the rat and human VIP1 receptor

Novel anti-HIF-1alpha agent

Water soluble derivative pro-drug of PG490 (triptolide)

Novel inhibitor of Profilin1 (Pfn1), reducing the overall level of cellular filamentous (F)-actin, slowing EC migration and proliferation, and inhibiting the angiogenic ability of EC both in vitro and ex vivo