Endogenous dipeptide, activating N-methyl-D-aspartate receptors

Natural non-covalent NRF2 activator, activating NRF2 in A KEAP1-dependent but Cys151-independent manner, conferring greater protection than a Cys151-dependent analog, geopyxin C

Natural covalent Cys151-dependent NRF2 activator

Metabolite of ganstigmine, a novel acetylcholinesterase inhibitor

Novel antifungal agent

MAO inhibitor

Novel Phosphodiesterase 4D (PDE4D) Inhibitor

Inhibitor of the Wnt/beta-catenin signaling pathway, suppressing cell proliferation and enhancing radiosensitivity in A549/Wnt2 cells.

Novel SMAC mimetic and IAP antagonist

Novel Bruton's tyrosine kinase (BTK) inhibitor

Novel potent, selective and orally bioavailable Chk1 inhibitor

Novel highly-selective oral checkpoint kinase 1 (Chk1) inhibitor

Novel glucosylceramide synthase (GCS) inhibitor, rescuing lysosomal deficits, α-synuclein pathology and neuron toxicity

Novel Potent and Selective Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes

Highly potent non-nucleoside inhibitor of HIV-1 reverse transcriptase

Selective inhibitor of carbonic anhydrase IX (CAIX)

Selective inhibitor of carbonic anhydrase IX (CAIX)

Novel non-toxic and mammalian-specific LINE-1 inhibitor

Antagonist of central cholecystokinin receptors

Novel CB1R allosteric agonist-positive modulator (ago-PAM), exhibiting augmented allosteric-agonist and PAM activities in neuronal cultures, improved metabolic stability, and enhanced orthosteric agonist binding (CP55940)

Novel CB1R allosteric agonist-positive allosteric modulator (ago-PAM), exhibiting moderate ago-PAM potency and improved aqueous solubility with therapeutic reduction of intraocular pressure in murine glaucoma models

Novel CB1R allosteric agonist-positive modulator (ago-PAM), exhibiting augmented allosteric-agonist and PAM activities in neuronal cultures, improved metabolic stability, and enhanced orthosteric agonist binding (CP55940)

Novel CB1R allosteric agonist biased toward G protein- vs β-arrestin1/2-dependent signaling

Novel potent CB1R ago-PAM

Novel allosteric activator and positive modulator of α7 nicotinic acetylcholine receptors (nAChR), more active (+)-enantiomer of 4BP-TQS

Novel GAS41 YEATS inhibitor, blocking proliferation of NSCLC cells, and modulating expression of GAS41-dependent genes, demonstrating on-target inhibition of GAS41 in cancer cells

Novel acetylcholinesterase inhibitor

Mammalian metabolite, identified in plasma and cerebrospinal fluid from hyperammonaemic patients

Natural antibiotic, displaying potent and selective bactericidal activity against key Gram-positive pathogens (including Staphylococcus aureus and enterococci)

Novel acid-tolerant green RSFP, exhibiting negative switching with especially high contrast in acidic conditions, and its off switching is caused by trans-to-cis isomerization of the chromophore hydroxyphenyl ring that accompanies protonation