Novel phosphodiesterase 4 (PDE4) inhibitor with little emetic potential, blocking MPP+ induced oxidative damage in SH-SY5Y cells and neurons via AMPK-dependent autophagy

Specific inhibitor of inflammasome assembly, targeting the NLRP3 inflammasome by interfering with the proximity-induced autocleavage of procaspase-1

Novel CAIX inhibitor, inhibiting breast cancer invasion and metastasis

Novel potent αvβ3 antagonist. reducing GBM tumor growth and viability by up to 98%

First-in-class covalent allosteric inhibitor of fructose-1,6-bisphosphate aldolase (FBA) from Candida albicans (CaFBA)

Potent and selective dopamine D3 receptor partial agonist

Highly potent and selective dopamine D4 receptor agonist

Dopamine D4 receptor antagonist

Novel irreversible dopamine D2 receptor ligand, covalently binding the L94C mutant of the dopamine D2 receptor

Dopamine D4 receptor antagonist

Novel folate-targeted TLR7 agonist, selectively accumulating in profibrotic macrophages and suppressing fibrosis-inducing cytokine production, reprograming M2-like fibrosis-inducing macrophages into fibrosis-suppressing macrophages, resulting in dramatic

Novel fatty acid synthase (FASN)

Novel potent and specific fatty acid synthase (FASN) inhibitor

Novel inhibitor of C. difficile's FASII pathway

Novel folate-caged pomalidomide-based anaplastic lymphoma kinase (ALK) PROTAC, effectively degrading ALK fusion proteins in cancer cells in a FOLR1-dependent manner

Stable and persistent PKC activator

Inducer of apoptosis via regulation of L11 and c-Myc with combinational potential with anticancer drugs in non-small-cell lung cancers

Novel FAP-targeted NIR dye conjugate

Novel FAP-targeted Fluorescein dye conjugate

Inhibitor of neutrophil superoxide production

Nonsteroidal anti-inflammatory drug (NSAID)

Potent and bioavailable irreversible inactivator of PAD4

Novel Fluorescent HIF-1α peptide

Novel highly potent FAK-targeting PROTAC degrader, showing a rapid and reversible FAK degradation

Novel blocker of focal adhesion kinase (FAK) autophosphorylation

Novel inhibitor of fungal fatty acid biosynthesis, demonstrating broad-spectrum activity against Candida auris and mucormycetes and retained the activity against azole-resistant candida isolates

Novel folate-appended 2-hydroxypropyl-ß-cyclodextrin (HP-ß-CyD), showing strong anti-leukemia and cell-binding activities, inhibiting the growth of FR-expressing cells, enterjng CML cells through endocytosis and inducing both apoptosis and autophagy via m

Novel Folate Receptor Targeting and Cathepsin B-Sensitive Drug Delivery System for Selective Cancer Cell Death and Imaging, exhibited strong cytotoxicity against FR-overexpressing SK-Hep-1, HeLa, and Siha cells, with IC50 values of 2-3 μM, but had no effe

Novel antileukaemic alkaloid; Inhibitor of reverse transcriptase activity of RNA-tumor viruses; Inhibitor of topoisomerase I

Novel factor VIIa inhibitor