Novel potent EZH2 inhibitor

Novel potent CBP bromodomain inhibitor with a TR-FRET IC50 value of 19.5 ± 1.1 nM and over 400-fold of selectivity against BRD4 bromodomains

Novel potent BPTF-BRD inhibitor, showing selectivities 100-fold higher than those of other BRD targets

Novel potent BPTF-BRD inhibitor, showing selectivities 100-fold higher than those of other BRD targets, significantly inhibiting leukemia cell proliferation

Inhibitor of N-methyl transferases (NMT), preventing the formation of Parkinson's syndrome neurotoxins via methylation of non-methylated pre-neurotoxins.

Novel inhibitor of menin-MLL interaction

Novel inhibitor of menin-MLL interaction

Novel inhibitor of menin-MLL interaction

Novel inhibitor of WDR5-MLL1 interaction

Novel selective non-nucleoside inhibitor of DNA methyltransferase 1 (DNMT1)

Potent HCV NS5A inhibitor

p38 MAPK inhibitor, supressing p38 phosphorylation and LPS-induced TNF-α production in macrophages

Novel protein cross-linking agent

Novel antileishmanial agent, against both intracellular Leishmania donovani and intracellular Leishmania amazonensis and displaying dose-dependent reduction of liver parasitemia

Novel ERG/DNA binding inhibitor, targeting the DNA-binding activity of the human ERG transcription factor

Novel tyrosine kinase inhibitor for drug resistant T315I mutant BCR-ABL

Biological Active Reagents

Novel selective ionotropic glutamate receptor 5 (iGluR5) antagonist

Novel glucagon analog for diabetic hypoglycemia therapy

Novel PROTAC targeting drug-resistant BCR-ABL

Proteolysis targeting chimeras (PROTAC), acting as a degrader of oncogenic BCR-ABL

Proteolysis targeting chimeras (PROTAC), acting as a degrader of oncogenic BCR-ABL

An impurity formed in Darapladib production

Potent Selective serotonin reuptake inhibitor (SSRI)

Novel inhibitor of L,L-diaminopimelate aminotransferase (DapL)

Potent and selective fluorescent adenosine A1 receptor agonist

Lipid bilayer modulator which likely inserts into lipid bilayers in the headgroup region, alters their structure and phase behavior, thins the bilayer and fluidizes it, allowing even saturated lipid to form fluid bilayers

Novel potent Bax inhibitor, showing concentration-dependent inhibition of liposome permeabilization with improved activity in vitro

Widely used fluorescent detector of nitric oxide in culture medium, tissue sections and biopsy cells

Selective inhibitor of human DPP7