Fmoc-Val-Ala-PAB-OH|CAS 1394238-91-5|DC Chemicals

Cas No.:	1394238-91-5
Chemical Name:	(9H-fluoren-9-yl)methyl (S)-1-((S)-1-(4-(hydroxymethyl)phenylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamate
Synonyms:	Fmoc-Val-Ala-PAB; ACD linker; Fmoc-Val-Ala-PAB-OH
SMILES:	C[C@@H](C(N)=O)N(C([C@H](C(C)C)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)=O)C4=CC=C(CO)C=C4
Formula:	C₃₀H₃₃N₃O₅
M.Wt:	515.60
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Fmoc-Val-Ala-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Target:	Cleavable
In Vitro:	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
References:	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Cat. No.	Product name	Field of application
DC39235	Fmoc-Val-Ala-PAB-OH	Fmoc-Val-Ala-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
DC46131	Acid-C3-SSPy	Acid-C3-SSPy is a cleavable DBA-DM4 linker used in the synthesis of DBA-DM4, a drug-linker conjugate for ADC.
DC44707	DBCO-S-S-acid	DBCO-S-S-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
DC43960	MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH	MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
DC42440	Fmoc-Gly-Gly-Phe-OH	Fmoc-Gly-Gly-Phe-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
DC41151	Boc-Dap-NE	Boc-Dap-NE, a dipeptide, is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
DC41150	Fmoc-3VVD-OH	Fmoc-3VVD-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
DC41143	MC-Gly-Gly-Phe-Gly	MC-Gly-Gly-Phe-Gly is a cleavable ADC linker used for antibody-drug conjugates (ADCs).
DC40833	MC-VC-PAB-Azide	MC-VC-PAB-Azide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
DC40831	Fmoc-Val-Ala-PAB-PNP	Fmoc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).