9322-O16B|Ionizable Lipid for LNP

Cas No.:	2909427-23-0
Chemical Name:	9322-O16B
Synonyms:	9322O16B, 9322 O16B
SMILES:	O=C(CCN(CCC(OCCSSCCCCCCCCCCCC)=O)CCCN1C=CN=C1C)OCCSSCCCCCCCCCCCC
Formula:	C₄₄H₇₇N₃O₄S₄
M.Wt:	804.3
Purity:	>95%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	Ye, Z., Chen, J., Zhao, X., et al. In vitro engineering chimeric antigen receptor macrophages and T cells by lipid nanoparticle-mediated mRNA delivery. ACS Biomater. Sci. Eng. 8(2), 722-733 (2022).

Cat. No.	Product name	Field of application
DC53130	93-O17S	93-O17S is an imidazole-based synthetic lipidoid for in vivo mRNA delivery. Lipid nanoparticles (LNPs) with 93-O17S promotes both the cross-presentation of tumor antigens and the intracellular delivery of cGAMP (STING agonist).
DC60495	9322-O16B	9322-O16B is a lipidoid for the efficient delivery of antiCD19 mRNA CAR to murine primary macrophages. LNP 9322-O16B is more efficient than delivery with lipofectamine 2000 (LPF2K) or MC3.
DC80065	113-O12B	113-O12B is a disulfide bond-containing ionizable cationic lipidoid. 113-O12B LNP, an LN-targeting LNP delivery system, is developed for a mRNA cancer vaccine. The 113-O12B/mRNA shows enhanced expression in APCs compared with ALC-0315/mRNA, indicating the LN-specific targeting ability.