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PROTAC CDK9 Degrader-1

  Cat. No.:  DC11564   Featured
Chemical Structure
2118356-96-8
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More than 5000 active chemicals with high quality for research!
Field of application
A heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9.
Chemicals PropertiesBiological activity Related products COA MSDS Datasheet
Cas No.: 2118356-96-8
Chemical Name: PROTAC CDK9 Degrader-1
Synonyms: PROTAC CDK9 Degrader-1;CDK9-PROTAC;N-(5-Cyclobutyl-1H-pyrazol-3-yl)-2-(4-((5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)pentyl)oxy)phenyl)acetamide;N-(5-cyclobutyl-1H-pyrazol-3-yl)-2-[4-[5-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxypentoxy]phenyl]acetamide;CS-0028478;N-(5-cyclobutyl-1H-pyrazol-3-yl)-2-{4-[(5-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}pentyl)oxy]phenyl}acetamide;HY-103628;CHEMBL4519788;AKOS037653368;SCHEMBL21691024;G16199;EN300-22891599;2118356-96-8;EX-A8716;DA-57124;N-(5-cyclobutyl-1H-pyrazol-3-yl)-2-{4-[(5-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxy}pentyl)oxy]phenyl}acetamide;PROTAC 6
SMILES: O(CCCCCOC1C=CC(=CC=1)CC(NC1C=C(C2CCC2)NN=1)=O)C1=CC=CC2C(N(C(C=21)=O)C1C(NC(CC1)=O)=O)=O
Formula: C33H35N5O7
M.Wt: 613.66
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9; selectively degrades CDK9 while sparing other CDK family members in HCT116 cells.
Cat. No. Product name Field of application
DC39826 Homo-PROTAC cereblon degrader 1 Homo-PROTAC cereblon degrader 1, is a cereblon degrader.
DC50038 PROTAC SGK3 degrader-1 PROTAC SGK3 degrader-1 (SGK3-PROTAC1), is a potent SKG3 degrader based on PROTAC. PROTAC SGK3 degrader-1 (0.3 μM) induces 50% degradation of endogenous SGK3 within 2 hours, with maximal 80% degradation observed within 8 hours, accompanied by a loss of phosphorylation of NDRG1 (an SGK3 substrate).
DC48434 TD-165 TD165(TD 165) is a PROTAC-based cereblon (CRBN) degrader that degrads Cav1.2α with the DC50 of 20.4 nM, comprising a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group.
DC48369 AGB1 AGB1 is a fast, highly selective, and potent bump-and-hole (B&H)-PROTAC degrader for BromoTag. AGB1 exhibits degradation for Ab:Brd4BD2 L387A and Ab: BromoTag-Brd2 with pDC50s of 7.8 and 7.9. AGB1 exhibits binary affinity to VHL (Kd=125 nM). AGB1 exhibits favorable pharmacokinetic profile in mice with the DC50, 6 h of ∼13 nM.
DC44429 Benzyl-PEG5-NHBoc Benzyl-PEG5-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
DC44034 Benzyl-PEG1-propanol Benzyl-PEG1-propanol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
DC40420 ARCC-4 ARCC-4 is a low-nanomolar androgen receptor (AR) degrader based on PROTAC, with a DC50 of 5?nM. ARCC-4 is an enzalutamide-based von Hippel-Lindau (VHL)-recruiting AR PROTAC and outperforms enzalutamide. ARCC-4 effectively degrades clinically relevant AR mutants associated with antiandrogen therapy.
DC28556 XY028-133 XY028-133 (example 14) is a PROTAC-based CDK4/6 degrader with anti-tumor activity, extracted from patent WO2018106870A1.
DC28539 SIAIS178 SIAIS178 is a potent and selective BCR-ABL degrader based on PROTAC technology with an IC50 of 24 nM. SIAIS178 causes effective degradation of BCR-ABL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. SIAIS178 has anticancer activity.
DC11590 Homo-PROTAC pVHL30 degrader 1 CM-11 is a homo-PROTAC, bivalent small-molecule dimerizer of the VHL E3 ubiquitin ligase to induce self-degradation.
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