TD-165|CAS 2305936-56-3|DC Chemicals

Cas No.:	2305936-56-3
Chemical Name:	TD-165
Synonyms:	TD 165;TD165
SMILES:	CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCNC3=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C(C)(C)C)C=C2)SC=N1
Formula:	C₄₆H₅₉N₇O₈S
M.Wt:	870.07
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera.Sci Rep. 2019 Dec 23;9(1):19654. [Content Brief]

Description:	TD-165 is a PROTAC-based cereblon (CRBN) degrader that degrads Cav1.2α with the DC50 of 20.4 nM, comprising a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group.
References:	[1]. Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera.Sci Rep. 2019 Dec 23;9(1):19654. [Content Brief]

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