CM11|CM-11;CM 11|CAS 2244684-49-7|DC Chemicals

Cas No.:	2244684-49-7
Chemical Name:	Homo-PROTAC pVHL30 degrader 1
Synonyms:	CM 11;CM11;Homo-PROTAC pVHL30 degrader 1
SMILES:	O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)COCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O
Formula:	C₅₈H₈₂N₈O₁₄S₂
M.Wt:	1179.44689321518
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	CM-11 is a potent pVHL30 degrader based on PROTAC[1].
Target:	pVHL30[1] PROTAC[1]
In Vitro:	Homo-PROTAC pVHL30 degrader 1 dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response[1].
References:	[1]. Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830.

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DC46405	ARD-2128	ARD2128 is a highly potent, orally bioavailable PROTAC androgen receptor (AR) degrader. ARD-2128 effectively reduces AR protein, suppresses AR-regulated genes in tumor tissues, and inhibits growth of tumor without signs of toxicity. ARD-2128 has the potential for the research of the prostate cancer.

Homo-PROTAC pVHL30 degrader 1