GRP-60367|RABV inhibitor| DC Chemicals

Cas No.:	1309241-34-6
Synonyms:	GRP-60367;GRP-60367;GRP-60367
SMILES:	O=C(C1C=CN=CC=1)N1CCC(NCCOC2C(C)=CC=C(C)C=2)CC1
Formula:	C₂₁H₂₇N₃O₂
M.Wt:	353.46
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Venice Du Pont, et al. Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor. J Virol. 2020 Jun 16;94(13):e00321-20.

Description:	GRP-60367 is a first-in-class small-molecule rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains[1].
Target:	RABV[1]
In Vitro:	GRP-60367 inhibits entry of a subset of RABV strains. GRP-60367 shows specific and potent anti-RABV activity of the scaffold, returning in dose-response assays EC50s ranging from 2 to 52 nM on different host cell lines[1].
References:	[1]. Venice Du Pont, et al. Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor. J Virol. 2020 Jun 16;94(13):e00321-20.

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