Hydroxy-PEG10-Boc(ADC Linker)|cas 778596-26-2|DC Chemicals

Cas No.:	778596-26-2
Chemical Name:	HO-PEG10-tBu
Synonyms:	HO-PEG10-CH2CH2COOtBu;HO-PEG10-tBu;Hydroxy-PEG10-t-butyl ester;tert-butyl 1-hydroxy-3,6,9,12,15,18,21,24,27,30-decaoxatritriacontan-33-oate
SMILES:	CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
Formula:	C₂₇H₅₄O₁₃
M.Wt:	586.71000
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Hydroxy-PEG10-Boc is extacted from patent CN108707228 (example 0024). Hydroxy-PEG10-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG10-Boc can be conjugated to Paclitaxel or docetaxel.
In Vitro:	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References:	[1]. Huli, et al. A kind of preparation method of hydroxyl polyethylene glycol propionic ester. Patent [2]. Miller ML, et al. Synthesis of taxoids with improved cytotoxicity and solubility for use in tumor-specific delivery.J Med Chem. 2004 Sep 23;47(20):4802-5.

Cat. No.	Product name	Field of application
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