KML-29|cas 1380424-42-9|DC Chemicals

Cas No.:	1380424-42-9
Chemical Name:	KML-29
Synonyms:	KML29;KML 29;1,1,1,3,3,3-Hexafluoro-2-propanyl 4-[bis(1,3-benzodioxol-5-yl)(hy droxy)methyl]-1-piperidinecarboxylate;KML 29;1,1,1,3,3,3-hexafluoroisopropylacrylate;1,1,1,3,3,3-hexafluoroprop-2-yl acrylate;1,1,1,3,3,3-hexafluoropropan-2-yl acrylate;Acrylic Acid 1,1,1,3,3,3-Hexafluoroisopropyl Ester;hexafluoro-2-propyl acrylate;Hexafluoroisopropyl acrylate;4-[bis(1,3-Benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester;1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate;KML29;SXHQLPHDBLTFPM-UHFFFAOYSA-N;GTPL9482;BDBM179929;BCP16466;US9133148, 1a;AK547299;1,1,1,3,3,3-hexafluoropropan-2-yl 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate;1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate;4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 2,2,2-triflu
SMILES:	FC(C([H])(C(F)(F)F)OC(N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])C(C1C([H])=C([H])C2=C(C=1[H])OC([H])([H])O2)(C1C([H])=C([H])C2=C(C=1[H])OC([H])([H])O2)O[H])=O)(F)F
Formula:	C₂₄H₂₁F₆NO₇
M.Wt:	549.4165
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

KML29 is a potent and selective MAGL inhibitor with IC50 = 5.9, 15, and 43 nM in human, mouse, and rat brain proteomes, respectively.IC50 value: 15, 43, and 5.9 nM (mouse, rat, and human brain proteomes)Target: MAGLin vitro: KML29 potently and selectively inhibits MAGL with minimal cross-reactivity toward other central and peripheral serine hydrolases, including no detectable activity against FAAH.[1]in vivo: KML29 a potentially very useful tool to explore the consequences of inhibiting MAGL in the whole animal and in multiple species, and provides greater selectivity than JZL184 in inhibiting MAGL. [2]

Cat. No.	Product name	Field of application
DC9990	URB602	URB602 is a selective inhibitor of monoglycerol lipase (MGL), exhibiting an IC50 of 28 µM for the rat brain enzyme.
DC10536	KML-29	KML29 is an O-hexafluoroisopropyl carbamate analog of JZL 184 that potently and selectively inhibits MAGL (IC50s = 15, 43, and 5.9 nM in mouse, rat, and human brain proteomes, respectively) over FAAH (IC50s >50 μM).
DC11464	DO-264	DO264 is an inhibitor of α/β-hydrolase domain-containing protein 12 (ABHD12; IC50 = 11 nM).It inhibits ABHD12-dependent hydrolysis of lysophosphatidylserine (lyso-PS) in mouse brain membrane lysates (IC50 = 2.8 nM) and human THP-1 cells.
DC11183	ABX-1431 hydrochloride	ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL).
DC11155	ABX-1431	ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL).