MDK7526|cas 1448189-80-7|DC Chemicals

Cas No.:	1448189-80-7
Chemical Name:	(S,R,S)-AHPC HCl
Synonyms:	Protein degrader 1 (hydrochloride);Protein degrader 1 hydrochloride;3-Methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide hydrochloride (1:1);(2s,4r)-1-((s)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-n-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride;E3 Ligase ligand;VH032;(S,R,S)-AHPC hydrochloride
SMILES:	O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl
Formula:	C₂₂H₃₁ClN₄O₃S
M.Wt:	467.025
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Protein degrader 1 hydrochloride is used in the synthesis of HaloPROTACs.
In Vitro:	Protein degrader 1 hydrochloride is used in the synthesis of HaloPROTACs.
References:	[1]. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.ACS Chem Biol. 2015 Aug 21;10(8):1831-7.

Cat. No.	Product name	Field of application
DC86101	VH032-cyclopropane-F	E3 ligase Ligand 19 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 19 can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4[1]
DC51007	Lenalidomide-5-aminomethyl hydrochloride	Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC
DC51006	Lenalidomide-4-OH	A Novel PROTACs building block.
DC71103	Pomalidomide-PEG4-COOH	Pomalidomide-PEG4-COOH is a E3 ligase ligand-linker conjugate. Pomalidomide-PEG4-COOH contains the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology (extracted from patent WO2017184995A1).
DC47216	Thalidomide-5,6-F	Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs.
DC41134	Thalidomide-5-OH	Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs.
DC12028	MDK7526(Protein degrader 1)	MDK7526, also known as VHL Ligand 1; Protein degrader 1, is a potent and selective protein degrader.
DC11571	E3 Ligase Ligand 3	E3 ligase Ligand 3 is a ligand of E3 ligase, used in PROTAC technology.
DC50061	Pomalidomide-C2-NH2(E3 ligase Ligand 17)	E3 ligase Ligand 17 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

MDK7526(Protein degrader 1)