Thalidomide-5-OH|CAS 64567-60-8|DC Chemicals

Cas No.:	64567-60-8
Chemical Name:	Thalidomide-5-OH
SMILES:	O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(O)=C3)=O
Formula:	C₁₃H₁₀N₂O₅
M.Wt:	274.23
Sotrage:	Powder-20°C3 years4°C2 yearsIn solvent-80°C6 months -20°C1 month

Description:

Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs[1].

Cat. No.	Product name	Field of application
DC86101	VH032-cyclopropane-F	E3 ligase Ligand 19 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 19 can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4[1]
DC51007	Lenalidomide-5-aminomethyl hydrochloride	Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC
DC51006	Lenalidomide-4-OH	A Novel PROTACs building block.
DC71103	Pomalidomide-PEG4-COOH	Pomalidomide-PEG4-COOH is a E3 ligase ligand-linker conjugate. Pomalidomide-PEG4-COOH contains the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology (extracted from patent WO2017184995A1).
DC47216	Thalidomide-5,6-F	Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs.
DC41134	Thalidomide-5-OH	Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs.
DC12028	MDK7526(Protein degrader 1)	MDK7526, also known as VHL Ligand 1; Protein degrader 1, is a potent and selective protein degrader.
DC11571	E3 Ligase Ligand 3	E3 ligase Ligand 3 is a ligand of E3 ligase, used in PROTAC technology.
DC50061	Pomalidomide-C2-NH2(E3 ligase Ligand 17)	E3 ligase Ligand 17 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].