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BTK-IN-24(NX-5948)

  Cat. No.:  DC60530   Featured
Chemical Structure
2649400-34-8
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More than 5000 active chemicals with high quality for research!
Field of application
NX-5948,be also known as BTK-IN-24,is an oral BTK degrader.
Cas No.: 2649400-34-8
Chemical Name: BTK-IN-24
Synonyms: 2-Pyrazinecarboxamide, 3-[[4-[1-[[1-[6-[[[(3S)-2,6-dioxo-3-piperidinyl]amino]carbonyl]-3-pyridinyl]-4-piperidinyl]methyl]-4-piperidinyl]phenyl]amino]-5-[(3R)-3-(3-methyl-2-oxo-1-imidazolidinyl)-1-piperidinyl]-;3-((4-(1-((1-(6-(((S)-2,6-dioxopiperidin-3-yl)carbamoyl)pyridin-3-yl)piperidin-4-yl)methyl)piperidin-4-yl)phenyl)amino)-5-((R)-3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl)pyrazine-2-carboxamide;BTK-IN-24
SMILES: C1(C(N)=O)=NC=C(N2CCC[C@@H](N3C(=O)N(C)CC3)C2)N=C1NC1=CC=C(C2CCN(CC3CCN(C4=CC=C(C(N[C@H]5CCC(=O)NC5=O)=O)N=C4)CC3)CC2)C=C1
Formula: C42H54N12O5
M.Wt: 806.955567836761
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Cat. No. Product name Field of application
DC68008 Tris-GalNAc-β-Ala-PEG3-FITC The trivalent β-GalNAc ligand is specific for Asialo Glycoprotein Receptors (ASGPR) on hepatocyte cells. β-Ala-PEG3 acts as linker/spacer between triantennary GalNAc and Fluorescein isothiocyanate (FITC).
DC68007 Tris-GalNAc-β-Ala-PEG3-MAL A thiol-reactive asialo glycoprotein receptor (ASGPR) ligand.
DC68006 Tri-GalNAc-PEG2000-DSPE Tris-GalNAc-GABA-NH2 linked via PEG2k to phospholipid (DSPE or 1,2-distearoyl-sn-glycero-3-phosphoethanolamine) where GABA = gamma-Aminobutyric acid, or γ-aminobutyric acid.
DC68005 Tris-GalNAc-PEG5-sulfo-NHS Ester An amine-reactive asialo glycoprotein receptor (ASGPR) ligand.
DC68004 Tris-GalNAc-β-Ala-PEG3-DBCO Triantennary GalNAc ligand is known to bind Asialo Glycoprotein Receptor (ASGPR). The ligand is functionalized with dibenzocyclooctyne for click chemistry.
DC68003 Tris-GalNAc-β-Ala-PEG4-DBCO Triantennary GalNAc ligand is known to bind Asialo Glycoprotein Receptor (ASGPR). The ligand is functionalized with dibenzocyclooctyne for click chemistry
DC68002 Tris-β-GalNAc-β-Ala-PEG3-N3 (β-D-GalNAc-sp)3-NHC(O)-(CH2)2-NHC(O)-PEG3-(CH2)2-N3 Tris-β-D-GalNAc ligands bind with asialoglycoprotein receptors (ASGPR) that are highly expressed on hepatocytes resulting in rapid endocytosis of the ligand along with conjugated payloads
DC68001 Tris-β-GalNAc-PEG3-Azide Trivalent β-GalNAc Ligand with discrete, monodisperse, azido-functionalized PEG3 linker/spacer
DC68000 Tris-GalNAc-β-Ala-PEG3-NH2
DC67999 Tris-GalNAc-Ahx-NH2
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