PT-179|PT179|DC Chemicals

Cas No.:	2924858-25-1
Chemical Name:	PT-179
Synonyms:	2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(4-morpholinyl)-
SMILES:	O=C1C2=CC(N3CCOCC3)=CC=C2C(N1C1CCC(NC1=O)=O)=O
Formula:	C₁₇H₁₇N₃O₅
M.Wt:	343.333984136581
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	Continuous evolution of compact protein degradation tags regulated by selective molecular glues-Science . 2024 Mar 15;383(6688):eadk4422. doi: 10.1126/science.adk4422. Epub 2024 Mar 15.

Description:	PT-179 is a new orthogonal immunomodulatory drug (IMiD) derivative that binds CRBN but does not induce degradation of off-target proteins. PT-179 potently degrades proteins fused to SD40 at either the N or C terminus.
References:	Continuous evolution of compact protein degradation tags regulated by selective molecular glues-Science . 2024 Mar 15;383(6688):eadk4422. doi: 10.1126/science.adk4422. Epub 2024 Mar 15.

Cat. No.	Product name	Field of application
DC60559	PT-179	PT-179 is a novel orthogonal immunomodulatory drug (IMiD) derivative that selectively binds to CRBN without inducing degradation of off-target proteins. It demonstrates potent activity in degrading proteins fused to SD40, regardless of whether the fusion occurs at the N or C terminus.
DC70978	Thalidomide-piperazine hydrochloride	Thalidomide-piperazine hydrochloride represents a chemically modified derivative of the prototypic immunomodulatory drug, featuring a piperazine moiety that enhances solubility while preserving the compound's unique biological properties.
DC28693	CC-90009	CC-90009 is a cereblon modulator that selectively binds to CRBN, influencing the activity of the ubiquitin E3 ligase complex. This interaction triggers the ubiquitination and subsequent proteasome-mediated degradation of specific transcription factors, such as Ikaros (IKZF1) and Aiolos (IKZF3), which act as transcriptional repressors in T-cells. By reducing the levels of these factors, CC-90009 modulates immune system activity, potentially leading to the activation of T-lymphocytes.
DC11588	CC-885	CC-885 (CC 885, CC885) is a novel modulator of the E3 ligase cereblon (CRBN) that exhibits strong anti-tumor activity by promoting the degradation of the protein GSPT1.