TPMPA|cas 182485-36-5|DC Chemicals

Cas No.:	182485-36-5
Chemical Name:	Phosphinic acid,P-methyl-P-(1,2,3,6-tetrahydro-4-pyridinyl)-
Synonyms:	Phosphinic acid,P-methyl-P-(1,2,3,6-tetrahydro-4-pyridinyl)-;(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate;TPMPA;(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinicacid;TPMPA hydrate;tpmpa hydrate;MFUKVPOVVKKLRQ-UHFFFAOYSA-N;(1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID;(1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID HYDRATE
SMILES:	CP(C1=CCNCC1)(=O)O
Formula:	C₆H₁₂NO₂P
M.Wt:	161.138742446899
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM). TPMPA has the potential for the research of suppressing orientation selectivity in ganglion cells[1][2][3].
Target:	KB: 2.1 μM (GABAC)
In Vitro:	TPMPA antagonizes the GABA currents of ρ1 receptors (IC50 = 1.6 μM) and those of the chimeric ρ1/α1 receptors with approximately the same potency (IC50 = 1.3 μM)[1]. TPMPA shows weak activity against rho-1 and rho-2 receptors, with the KB values of 2.0 and 15.6 μM, respectively[2]
References:	[1]. Martínez-Torres A, et al. GABArho 1/GABAAalpha 1 receptor chimeras to study receptor desensitization. Proc Natl Acad Sci U S A. 2000;97(7):3562-3566. [2]. Graham A. R. Johnston, et al. Neurologically-active compounds. WO1998058939A1 [3]. Johnston GA. GABAc receptors: relatively simple transmitter -gated ion channels?. Trends Pharmacol Sci. 1996;17(9):319-323.

Cat. No.	Product name	Field of application
DC72829	Zuranolone	Zuranolone(SAGE-217, CS-2797) is an orally active and potent neuroactive steroid and positive allosteric modulator of the GABAA receptor, with EC50s of 296 nM for α1β2γ2 receptor.
DC47051	Temgicoluril	Tetramethylglycerol (Tetramethylglycoluril) is a small molecule that acts on GABA Receptor, with anti-anxiety activity.
DC28164	Ro15-4513	Ro15-4513, imidazobenzodiazepinone derivative, is a partial inverse agonist of benzodiazepine receptor (BZR). Ro15-4513 is a potent ethanol antagonist. Ro15-4513 has anti-anxiety effect.
DC28110	FG 7142	FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the
DC9541	Vigabatrin	Vigabatrin(γ-Vinyl-GABA; Sabril) is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase. IC50 value: Target: GABA transaminase Clinical studies have sh
DC11319	TPMPA	TPMPA is a GABAA-ρ1 (ρ1 GABAC) receptor antagonist that is 8-fold selective for GABAA-ρ1 over GABAA-ρ2 (ρ2 GABAC) receptors expressed in X.
DC10651	SSD114 hydrochloride	SSD114 is a novel GABAB positive allosteric modulator.
DC8821	Etifoxine Hydrochloride	Etifoxine Hydrochloride is a psychotropic agent with anxiolytic and anticonvulsant activity. Etifoxine Hydrochloride is an activator of GABAA R β2 and GABAA R β3.
DC11657	PPT(Propyl pyrazole triol )	Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%).
DC10311	Allopregnanolone	Allopregnanolone is a progesterone metabolite. Allopregnanolone is an allosteric modulator of the GABA receptor.