Novel selective sigma 1 receptor (S1R) antagonist, exhibiting potent binding affinity for S1R, high selectivity over S2R and 87 other human targets, acceptable in vitro metabolic stability, slowing clearance in liver microsomes, and excellent blood-brain

Novel potent and selective agonist activity for S1PR4

Selective and highly potent alpha2-adrenoceptor agonist

Novel, Potential Antipsychotic Displaying Marked Antagonist Properties at α1- and α2-Adrenergic Receptors

Potent and selective thrombin inhibitor for the treatment of thromboembolic disorders

Inhibitor of NADPH oxidase, preventing the structural and functional sequelae of diet-induced metabolic heart disease

Potent, orally active, partial 5-HT1A receptor agonist

Potent 5-HT1A receptor agonist, also acting as a 5-HT2A and 5-HT2C receptor antagonist

Novel inhibitor of D-cyclin transactivation via phosphoinositide 3-kinase pathway

Novel HIV-1 integrase inhibitor

FP receptor agonist

Inverse agonist of the constitutive androstane receptor (CAR)

Highly Potent and Selective Butyrylcholinesterase (BChE) Inhibitor for Cognitive Improvement and Neuroprotection

Highly Potent and Selective Butyrylcholinesterase (BChE) Inhibitor for Cognitive Improvement and Neuroprotection

Novel highly effective tyrosinase inhibitor with great potential to be utilized in anti-Parkinsonian syndrome

The most viable GPVI modulator, acting as a potent antithrombotic agent

Selective D2 dopamine receptor antagonist; Precursor to radiolabeled S-(-)-raclopride

Partial 5-HT1A serotonin receptor agonist

The first Small Molecule RXFP3/4 Agonist, Increasing Food Intake in Rats Upon Acute Central Administration

Novel small molecule inhibitor of protein interaction with glycosaminoglycans (SMIGs), exercising broad spectrum anti-inflammatory activity by inhibition of protein binding to the cell surface GAG, heparan sulfate

Novel CD45 phosphatase inhibitor

Selective antagonist of protease activated receptor-1

Potent and selective of the benzodiazepine site on GABA(A) receptors

Inhibitor of LFA-1/ICAM-1 Mediated Cell Adhesion

Natural potent macrophage uptake enhancer of S. aureus and zymosan A bioparticles

Novel specific RUVBL1/2 ATPase inhibitor, radiosensitizing NSCLC, but not normal lung epithelial cells

Inhibitor of Adipogenesis/Lipogenesis with AMPK Activation and UPR Suppression, Reducing Lipid Accumulation in Adipocytes

Novel Ricin Inhibitor, Targeting Ribosome Binding

Novel Ricin Inhibitor, Targeting Ribosome Binding

Novel Ricin Inhibitor, Targeting Ribosome Binding