Novel Potent Non-peptidic Inhibitor of Secreted Aspartic Protease 2 (SAP2) for the Treatment of Resistant Fungal Infections

Novel potent inhibitor of Shh signaling pathway

Uridyl peptide antibiotic, exhibiting antibacterial activity against Mycobacterium tuberculosis H(37)Ra and Pseudomonas aeruginosa with MIC values of 10 and 12.5 mug/ml, respectively

Vasopeptidase or dual inhibitor of ACE and neutral endopeptidase with potential application in the treatment of hypertension and congestive heart failure

Natural antimicrobial and antitumor agent, inducing reactive oxygen species (ROS), and alterating heme biosynthesis

Opioid receptor antagonist for the treatment of alcoholism and cocaine addiction

Novel potent V-ATPase inhibitor, blocking viral entry

Antibiotic, Inhibiting CD44 expression in breast cancer cells and mammary tumor growth

ß2-adrenoceptor agonist

Natural α-glucosidase inhibitor, potently modulating Nrf 2 , NF-κB and STAT3 pathways

Natural α-glucosidase inhibitor

Novel Endogenous Reactive oxygen species (ROS)-activated HDAC inhibitor prodrug, demonstrating selective activity against multiple cancer cell lines such as HeLa, MCF-7, MDA-MB-231 and B16-F10, while remaining benign to non-cancer cells

Novel clickable HDAC inhibitor, selectively labeling HDAC complex proteins

Novel Smoothened receptor agonist

Irreversible and nonselective Monoamine_oxidase_inhibitor>monoamine oxidase inhibitor (MAOI)

Peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibiting gastrointestinal motility with no effect on experimental colitis in mice

Novel ileal Na /bile acid cotransporter inhibitor

Partial benzodiazepine inverse agonist, showing antidepressant-like pharmacological activity and acting as a cognitive enhancer

Novel Analogue of SUN-B8155, acting as a cell active and functionally-relevant agonist of calcitonin receptor (CTR), inducing different Gs or arrestin activities through CTR

Dual PPARα/γ agonist

Novel glucokinase (GK) activator

Novel glucokinase (GK) activator

Potent inhibitor of glucose-6-phosphate translocase (G6P T1)

Novel modulator of the retrograde signaling including cellular responses to hypoxic and oxidative stress, selectively eliminating superoxide production by complex III without altering oxidative phosphorylation

Potent and selective inhibitor of constitutive Stat3 DNA-binding and transcriptional activities

alpha2-Adrenoceptor Antagonist, Norepinephrine Transporter (NET) Inhibitor, Serotonine Transporter (SERT) Inhibitor

Potent quinone reductase 2 (QR2) inhibitor

Potent activator of the AMP-activated protein kinase (AMPK)

Potent and selective ligand of imidazoline 1 receptor (I1R)

Potent and selective ligand of imidazoline 1 receptor (I1R)