Novel selective 5-HT 2C agonist with >300-fold functional selectivity over 5-HT 2B and >70-fold functional selectivity over 5-HT 2A , reducing food intake in an acute rat feeding model

Serotonin metabolite, systemically inhibiting RAS/MAPK signaling in different organs of C. elegans

Novel palladium-activated 5-FU prodrug, being completely innocuous to cells and highly resistant to metabolization by primary hepatocytes and liver S9 fractions (the main metabolic route for 5-FU degradation), and rapidly converted into 5-FU in the presen

Rare base found in mammalian DNA, having functional roles in DNA that go beyond being a demethylation intermediate

HIV-1 integrase inhibitor

Novel HIV-1 integrase inhibitor

Novel potent δ-selective allosteric modulator, Ki(α4β1δ) 0.14 µM

Novel potent δ-selective allosteric modulator, Ki(α4β1δ) 0.06 µM

Brominated luciferin, being more cell permeant than luciferin

Adenosine kinase inhibitor

Novel Inducer of G2/M arrest, Apoptosis and Autophagy in Cancer Cells

Novel inhibitor of HCV NS3-NS4A Serine Proteinase

Inhibitor of T-type voltage-gated calcium channels (Cav3), inhibiting isoforms Cav3.1, Cav3.2, and Cav3.3, decreasing nifedipine-resistant phenylephrine-induced vasoconstriction via Cav3.2 blockade

Bulding Block

Useful pharmaceutical building block

Useful pharmaceutical building block

Inhibitor of Androgen_receptor>androgen receptor (AR) transcriptional activity, more effective than resveratrol in inhibiting AKT>Akt phosphorylation

Novel anti-austerity agent, inducing PANC-1 human pancreatic cancer cell death under nutrition starvation via inhibition of Akt/mTOR pathway

Novel ligand for LTA4H, dose responsively reducing LTB4 production in human neutrophils

Novel Potent and Selective Kappa Opioid Receptor Antagonist

Dopamine reuptake inhibitor

Potent agonist of tropomyosin-receptor-kinase B (TrkB) receptor, possessing robust anti-apoptotic activity, promoting neurogenesis, and exhibiting potent antidepressant effect

Potent Antifungal Inhibitor of Chitin Synthesis

Novel selective ligand of the Transport Inhibitor Resistant 1 (TIR1)

Prodrug of 7-Cl-kynurenic acid (7-Cl-KYNA), a potent, selective antagonist of the NMDA/glycine receptor

Novel Transthyretin (TTR) Amyloidogenesis Inhibitor, stabilizing the TTR tetramer by binding to the allosteric sites on the molecular surface of the TTR tetramer

Ca ionophore. potentiating responses to NMDA, but not quisqualate

Photoreactive L-phenylalanine derivative, being as a photo cross-linking probe to incorporate into proteins, including ion channels, transporters and GPCRs

Clickable fluorescent probe, enabling dynamic imaging of cell surface and intracellular fucosylation of glycoproteins and glycolipids.

Mutually Orthogonal Bioorthogonal Amino Acid, Enabling Efficient Protein Dual-Labeling in Cells