Necrostatin-7 is a necroptosis inhibitor. It acts by inhibiting TNF-alpha-induced necroptosis in a FADD-deficient variant of human Jurkat T cells.

Phox-I2 is a second generation inhibitor of the p67phox interaction with Rac1, effective in suppressing reactive oxygen species production by human and murine neutrophils.

Norchlorcyclizine is a partially selective NPR-B inhibitor. It also acts as an inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1).

o-3M3FBS is a negative control for m-3M3FBS, an activator of phospholipase C (PLC).

Sulbutiamine is an antioxidant that act by inhibiting oxidative stress induced retinal ganglion cell death.

VU0071063 is an activator of Kir6.2/SUR1.

Diclofensine HCl is an antidepressant with equipotent inhibitive effects on the neuronal uptake of norepinephrine (NE), serotonin, and dopamine.

LUF5834 is a potent nonribose agonist, activating A2A and A2B adenosine receptor.

DCAI is an inhibitor of nuleotide exchange and nucleotide release. It acts by binding to the pocket adjacent to the Ras-SOS interface.

ITX3 is a nontoxic selective cell active inhibitor of the Trio/RhoG?/Rac1 pathway. It acts by validating RhoGEFs as druggable targets.

Pyrazofurin is an inhibitor of human dyskerin. It is also an antiviral agent.

TN-16 is a tubulin inhibitor.

1,4-DPCA is a potent and selective inhibitor of prolyl 4-hydroxylase.

Acetyl-L-carnitine is a stimulator of α-secretase activity and metabolism of amyloid precursor protein (APP). It has been shown to induce NF-κB-mediated upregulation of mGluR2 receptors, thereby exhibiting antidepressant, neuroprotective, analgesic, and antinociceptive activities.

SDM-25N HCl is a selective δ-opioid receptor antagonist.

4-CPI is an inhibitor of non-active site mutants of cytochrome P450 2B4.

PMSF is an inhibitor of serine proteases such as trypsin and chymotrypsin. It also inhibits cysteine proteases (reversible by reduced thiols) and mammalian acetylcholinesterase.

CCT036477 is a selective inhibitor of wingless-type MMTV integration site family (WNT)-dependent transcription. It reduces the transcriptional activity of the T-cell factor/lymphoid enhancer factor transcription factor family at the ?-catenin level.

DL-Adrenaline is a non-selective adrenoceptor agonist. It induces lipolysis and systemic muscle contraction, and shows systemic vasoconstrictive, bronchodilatory, positive chronotropic and gastrointestinal relaxant effects in vivo.

Bronidox is an antimicrobial agent. It works by inhibiting enzyme activity in bacteria.

Tiamenidine is a centrally-acting alpha1 adrenergic receptor antagonist.

Succimer is an orally active heavy metal chelator.

PCB118 is a polychlorinated biphenyl, and an environmental contaminant. PCB118 induces inflammatory responses in the thyroid through a JNK and aryl hydrocarbon receptor-mediated pathway.

Ani9 is a potent ANO1 inhibitor. Anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A), a calcium-activated chloride channel (CaCC), is involved in many physiological functions such as fluid secretion, smooth muscle contraction, nociception and cancer progression. Ani9 may be a useful pharmacological tool for studying ANO1 and a potential development candidate for drug therapy of cancer, hypertension, pain, diarrhea and asthma.

5-Methylurapidil is an alpha1A-adrenoceptor antagonist. It has also been used for competitive binding in radioligand binding assays.

JX-401 is a p38alpha inhibitor containing a 4-benzylpiperidine motif. p38alpha is hyperactive in inflammatory diseases, and various indications suggest that its inhibition would reverse inflammation.

Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action.

L-703606 Oxalate is a tachykinin NK1 receptor antagonist.

Nafronyl Oxalate is a a selective antagonist of 5-HT2 receptors. Nafronyl Oxalate is a vasodilator used in the management of peripheral and cerebral vascular disorders. It is also claimed to enhance cellular oxidative capacity.

Trimebutine Maleate is a drug with antimuscarinic and weak mu opioid agonist effects. Trimebutine Maleate modulates the calcium and potassium channels, relieves abdominal pain in patients with irritable bowel syndrome. Trimebutine Maleate is used for treatment of irritable bowel syndrome and other gastrointestinal disorders.