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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC35566 m-PEG3-aldehyde
m-PEG3-aldehyde is a PEG derivative containing an aldehyde group. Aldehyde is reactive to hydrazide and aminooxy groups which are commonly used in biomolecular probes for labeling and crosslinking carbonyls (oxidized carbohydrates). The hydrophilic PEG spacer increases solubility in aqueous media.
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DC35492 PEG21
PEG21 is a PEG Linker. PEG Linkers may be useful in the development of antibody drug conjugates.
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DC35491 PEG18
PEG18 is a PEG Linker. PEG Linkers may be useful in the development of antibody drug conjugates.
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DC35485 Nonaethylene glycol
Nonaethylene glycol is a PEG Linker. PEG Linkers may be useful in the development of antibody drug conjugates.
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DC35450 Azide-PEG8-alcohol
Azide-PEG8-alcohol is a PEG derivative containing an azide group and a terminal hydroxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
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DC35254 Azidoethyl-SS-ethylazide
Azidoethyl-SS-ethylazide is a cleavable PEG Linker. PEG Linkers may be useful in the development of antibody drug conjugates.
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DC35221 Bromo-PEG3-bromide
Bromo-PEG3-bromide is a PEG derivative containing two bromide groups. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
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DC35220 Bromo-PEG2-bromide
Bromo-PEG2-bromide is a PEG derivative containing two bromide groups. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
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DC35067 Biotin-PEG2-Mal
Biotin-PEG2-Mal is a PEG derivative containing a biotin group and a maleimide group for labeling and crosslinking cysteines and other sulfhydryls. The maleimide group reacts specifically with sulfhydryl groups (at pH 6.5-7.5) to form a stable, irreversible thioether linkage. The hydrophilic PEG spacer increases solubility in aqueous media and increases membrane impermeability of the molecules conjugated to the biotin compound. It also helps to minimize steric hindrance involved with the binding to avidin molecules.
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DC34935 m-PEG24-amine
m-PEG24-amine is a PEG derivative containing an amino group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. PEG Linkers may be useful in the development of antibody drug conjugates and drug delivery methods.
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DC34912 Amino-PEG7-amine
Amino-PEG7-amine is a PEG derivative containing two amino groups. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. PEG Linkers may be useful in teh development of antibody drug conjugates.
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DC34760 NHS-Biotin
NHS-Biotin, Succinimidobiotin, is a primary amine reactive biotinylation reagent used in Biotin-Streptavidin binding reactions. The NHS-Biotin molecule is cell membrane permeable and can be used to covalently label intracellular proteins.
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DC34697 Phorate
Phorate is a cholinesterase inhibitor that is used as a broad-spectrum antibiotic. Its residues and metabolites may persist in soil, and may be toxic.
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DC34686 Temefos
Temefos is an organothiophosphate insecticide.
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DC34681 Oxamyl oxime
Oxamyl oxime is an agricultural chemical and pesticide.
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DC34673 Butralin
Butralin is a herbicide and plant-growth-controller.
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DC34646 Aminophylline
Aminophylline is an inhibitor of cAMP or cGMP phosphodiesterases, increasing levels of the second messenger cAMP or cGMP intracellularly, also acting as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart.
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DC34642 Valerenic acid
Valerenic acid is a ?-subunit-dependent GABAA receptor modulator.
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DC34631 Isoflupredone Acetate
Isoflupredone Acetate is a topical anti-inflammatory corticosteroid.
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DC34630 Diflorasone Diacetate
Diflorasone Diacetate is a topical glucocorticoid with anti-inflammatory and immunosuppressive properties.
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DC34626 Arzanol
Arzanol is a positive modulator of brain glycogen phosphorylase.
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DC34625 4-Octyl Itaconate
4-Octyl Itaconate is a cell permeable activator of Nrf2 which inhibits LPS-induced increases in IL-1β mRNA, HIF-1α, and IL-10 in macrophages.
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DC34621 Sulindac Sulfide
Sulindac Sulfide is a metabolite of sulindac.
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DC34583 gp130-agonist-2
gp130-agonist-2 is a brain penetrant gp130 agonist which protects against NMDA-induced toxicity and increases STAT3 phosphorylation.
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DC34567 L48-H37
L48H37 is a specific myeloid differentiation 2 (MD2) inhibitor.
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DC34563 HC3
Hemicholinium-3 is a competitive antagonist of CHT-mediated choline transport.
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DC34527 MMG11
MMG-11 is a potent and selective dual inhibitor of TLR2/1 and TLR2/6 signaling with low cytotoxicity.
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DC34461 IMB-10
IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo.
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DC34440 6-CFDA
6-CFDA is a cell membranes permeatable non-fluorescent prodrug of 5-carboxyfluorescein. It shows strongly fluorescent to differentiate viable cells from apoptotic cells after being enzymatically hydrolyzed inside cells.
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DC34426 2002-H20
2002-H20 is an inhibitior of Aβ42-induced cytotoxicity. It acts by binding the Alzheimer's Aβ peptide and reducing its cytotoxicity.
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